In relation to a new case of scleredema "adultorum" (Buschke) observed by authors in a two year-old girl, they compare characteristics of this type of cutaneous induration with those of sclerodermia. Scleredema affects the neck region, face and upper thorax, and very rarely it reaches the hands, meanwhile in sclerodermia the hands and face, and some other possible cutaneous region and viscera are commonly affected. The former regresses in six months to two years, or rarely later; the second is progressive and permanent. Histologically, dermal collagen in increased in both but in the former the fibers are not condensed and hyalinized, as they are in the second.

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  • * A case is presented involving a 14-year-old girl from Iran who experienced rapid progression of skin thickening, ruled out for malignancies and connective tissue disorders before being diagnosed with scleredema.
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[Differential diagnosis of sclerosing skin diseases: scleredema adultorum of Buschke].

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March 2024

Abteilung für translationale Dermatoinfektiologie, Westfälische Wilhelms-Universität Münster, Röntgenstr. 21, 48149, Münster, Deutschland.

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  • Scleredema adultorum of Buschke is a condition characterized by thickening of the skin, particularly starting at the neck and spreading, which can limit mobility due to increased dermal stiffness.
  • Diagnosis relies on histological evidence of mucin deposits and is differentiated from other sclerosing diseases, with three subtypes linked to infections, paraproteins, or diabetes.
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  • * It causes skin thickening and stiffness, starting at the neck and moving to the upper body, but generally avoids the palms and soles; mild cases may have no symptoms, while severe cases can lead to functional impairments.
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  • Cleredema of Buschke is a rare connective tissue disorder that causes thick, woody skin primarily in the arms.
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  • The goal of sharing this case is to help build a research database for understanding the occurrence, causes, and treatment of this uncommon condition.
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