Using a new experimental paradigm to evaluate physical activity in the natural environment, the authors made of 45,694 observations of persons using stairs or an adjacent escalator at a shopping mall, train station, and bus terminal. In study 1, stair use more than doubled for both obese and nonobese persons during two-week periods when a colorful sign encouraging use of the stairs was positioned at the stairs/escalator choice point. In study 2, stair use remained elevated for 15 consecutive days while the sign was present, decreased during a 1-month follow-up period, and returned to baseline by 3 months. These results not only demonstrate the usefulness of this paradigm, but also suggest the strength of simple, inexpensive public health interventions to increase physical activity.
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http://dx.doi.org/10.1176/ajp.137.12.1540 | DOI Listing |
Proc Natl Acad Sci U S A
January 2025
Experimental Physics V, Department of Physics, University of Bayreuth, D-95447 Bayreuth, Germany.
Photosynthetic microbes have evolved and successfully adapted to the ever-changing environmental conditions in complex microhabitats throughout almost all ecosystems on Earth. In the absence of light, they can sustain their biological functionalities through aerobic respiration, and even in anoxic conditions through anaerobic metabolic activity. For a suspension of photosynthetic microbes in an anaerobic environment, individual cellular motility is directly controlled by its photosynthetic activity, i.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Faculty of Life Sciences and Medicine, Harbin Institute of Technology Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China.
Lysophosphatidic acid (LPA) exerts its physiological roles through the endothelialdifferentiation gene (EDG) family LPA receptors (LPAR1-3) or the non-EDG family LPA receptors (LPAR4-6). LPAR6 plays crucial roles in hair loss and cancer progression, yet its structural information is very limited. Here, we report the cryoelectron microscopy structure of LPA-bound human LPAR6 in complex with a mini G or G protein.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
January 2025
Department of Civil and Architectural Engineering, Sultan Qaboos University, Muscat, Oman.
Assessing groundwater contamination risk is a critical aspect of preventing and managing groundwater pollution. There was a research gap in the investigation of uncertainties in modeling groundwater contamination risks in aquifers. This study addresses this gap using Bayesian Model Averaging (BMA), with a novel focus on risk exposures from geogenic contaminants, such as lead (Pb).
View Article and Find Full Text PDFEnviron Monit Assess
January 2025
College of Resources and Environment, Fujian Agriculture and Forestry University, Fuzhou, 350000, China.
This study expands the original two-dimensional carbon footprint model into a three-dimensional model form. Introduce two indicators of carbon footprint depth (CF) and size (CF) to form a three-dimensional carbon footprint model (CF), which is used to respectively represent the occupation and consumption of natural capital reserves by human activities' carbon emissions. Based on the 3D carbon footprint model, this paper calculated the CF, CF, and CF for four different urban agglomerations of China (BTH, YRD, PRD, and CY) spanning from 2000 to 2017.
View Article and Find Full Text PDFMikrochim Acta
January 2025
Public Health School, Mudanjiang Medical University, Mudanjiang, China.
Natural enzymes are a class of biological catalysts that can catalyze a specific substrate. Although natural enzymes have catalytic activity, they are susceptible to the influence of external environment such as temperature, and storage requirements are more stringent. Since the first discovery of magnetic FeO nanoparticles with peroxidase-like activity in 2007, the research on nanoenzymes has entered a rapid development stage.
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