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Associations of reverse triiodothyronine serum levels with anxiety, depression, and health related quality of life after experiencing acute ischemic stroke.
Front Neurol
January 2025
Laboratory of Behavioral Medicine, Neuroscience Institute, Lithuanian University of Health Sciences, Palanga, Lithuania.
Aim: This study intended to explore associations of reverse triiodothyronine (rT3) with emotional disturbances and health-related quality of life (HRQoL) after experiencing acute ischemic stroke (AIS).
Materials And Methods: Serum samples from individuals with AIS were collected on admission to three Lithuania stroke centers and investigated for free tetraiodothyronine, free triiodothyronine (fT3), rT3, and thyroid stimulating hormone levels. At discharge, emotional disturbance was evaluated using the Hospital Depression and Anxiety Scale (HADS), and HRQoL using the EQ-5D-5L scale.
Distribution of Polybrominated Diphenyl Ethers (PBDEs) in Placental Tissues of Maternal and Fetal Origin in Exposed Wistar Rats and Associations with Thyroid Hormone Levels.
Toxicol Sci
November 2024
Nicholas School of the Environment, Levine Science Research Center, Duke University, Durham, NC 27710.
In utero exposure to polybrominated diphenyl ethers (PBDEs) is linked to adverse pregnancy and fetal health outcomes, including altered thyroid hormone (TH) levels. Despite their phase out, PBDEs are still commonly detected in newborn cord blood. While PBDEs can cross the placenta, few studies have separately assessed PBDEs or THs in the maternal and fetal placental tissues.
View Article and Find Full Text PDFAssociation of COVID-19 with thyroid dysfunction and autoimmune thyroid disease: A retrospective cohort study.
J Transl Autoimmun
December 2024
Department of Nuclear Medicine, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaan Xi Province, 710004, China.
Background: Since the end of the COVID-19 pandemic, the potential roles of thyroid-inflammatory derangements in driving or being associated with the prognosis of COVID-19 remain controversial. We aimed to clarify the association between COVID-19 infection and thyroid dysfunction, and highlight the impacts of subsequent autoimmune thyroid disease (AITD) on the prognosis of COVID-19.
Methods: The retrospective, multicenter, cohort study enrolled 2,339 participants with COVID-19 from three hospitals located in the north, middle, and south regions of Shaan Xi Province, China, between December 2022 and July 2023.
Efficacy and safety of resmetirom among patients with non-alcoholic steatohepatitis: a systematic review and meta-analysis.
Ann Med Surg (Lond)
September 2024
Department of Medicine, Kabul University of Medical Sciences, Kabul, Afghanistan.
Article Synopsis
- Non-alcoholic steatohepatitis (NASH) is a serious illness with limited treatment options, and the FDA has recently approved resmetirom, a drug targeting the thyroid hormone receptor, for its treatment.
- In a review of four randomized controlled trials, resmetirom notably improved MRI-proton density fat fraction, reduced liver fat by 30%, and resolved NASH without fibrosis, although effects on certain liver enzymes were mixed.
- Resmetirom was linked to significant drops in various lipid levels (like triglycerides and LDL), but it also increased the likelihood of side effects such as diarrhea and nausea in patients.
Assessing the impact of triiodothyronine treatment on the lung microbiome of mice with pulmonary fibrosis.
BMC Pulm Med
August 2024
State Key Laboratory of Cell Differentiation and Regulation; Henan International Joint Laboratory of Pulmonary Fibrosis; Henan Center for Outstanding Overseas Scientists of Organ Fibrosis; Pingyuan Laboratory; College of Life Science , Henan Normal University, No.46 Jianshe Road, Xinxiang City, 453007, Henan, China.
Background: Idiopathic pulmonary fibrosis (IPF), an interstitial lung disease, is characterized by the exacerbation of progressive pulmonary fibrosis (PF). IPF primarily affects older individuals and can lead to respiratory failure. This study aimed to assess the effects of triiodothyronine (T) treatment on the lung microbiome of mice with PF.
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