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The Different Paths That Lead to Hypotonic Hyponatremia, and a Safe Approach to Treatment.
J Clin Med
December 2024
NYU Grossman Long Island School of Medicine, 101 Mineola Blvd., Mineola, NY 11501, USA.
A knowledge gap may exist when attempting to identify the pathogenetic mechanisms resulting in the syndrome of inappropriate antidiuretic hormone (SIADH) or hypotonic hyponatremia. Ectopic secretion of antidiuretic hormone [ADH] is the classic cause of SIADH. But another form of inappropriate secretion of ADH occurs when interleukin 6 is activated.
View Article and Find Full Text PDF[Systemic lupus erythematosus involving the fornix column leading to hyponatremia: A case report].
Beijing Da Xue Xue Bao Yi Xue Ban
December 2024
Department of Rheumatology, Peking University Third Hospital, Beijing 100191, China.
We reported the diagnostic and therapeutic process of a young male patient with systemic lupus erythematosus (SLE) who presented with severe hyponatremia as the main manifestation upon admission, and analyzed and discussed the case. The patient was a 19-year-old young male with a subacute course of disease, fever ≥38.3 ℃ that could not be explained by other causes, acute and subacute cutaneous lupus erythematosus, oral ulcers, arthritis, leukopenia (< 4×10/L), low C3+low C4, and positive anti-double-stranded DNA (anti-dsDNA).
View Article and Find Full Text PDFEctopic olfactory neuroblastoma is associated with increased frequency of syndrome of inappropriate antidiuretic hormone secretion and reduced disease control: Case series with systematic review and pooled analysis.
Int Forum Allergy Rhinol
January 2025
Section of Otorhinolaryngology-Head and Neck Surgery, Department of Neuroscience, University of Padova, Padova, Italy.
Introduction: Olfactory neuroblastoma (ONB) is a rare malignant tumor originating from the olfactory neuroepithelium, typically within the sinonasal cavity. Cases of ONB originating outside of the olfactory cleft area are extremely rare and are referred to as "ectopic" (eONB), in contrast to "orthotopic" tumors (oONB). ONB has been associated with paraneoplastic syndromes (PNSs), including the syndrome of inappropriate antidiuretic hormone secretion (SIADH).
View Article and Find Full Text PDFLong-Term Persistence of Inappropriate Antidiuretic Hormone Secretion Following Minor Head Injury.
Eur J Case Rep Intern Med
November 2024
Department of Internal Medicine, Iris Hospitals South (Molière), Brussels, Belgium.
Unlabelled: The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a common cause of euvolemic hyponatremia, resulting from non-osmotic release of antidiuretic hormone (ADH). SIADH is frequently associated with neurological conditions, including traumatic brain injury (TBI). TBI-associated SIADH usually develops within days to weeks and resolves within a few weeks.
View Article and Find Full Text PDFUnraveling the Mystery of Rathke's Cleft Cyst Presenting with Hyponatremia: A Case Report with a Comprehensive Review of Literature.
Asian J Neurosurg
December 2024
Department of Neurosurgery, Lenox Hill Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, New York, United States.
Article Synopsis
- Rathke's cleft cyst (RCC) is a benign cyst that usually goes unnoticed but can be associated with rare cases of hyponatremia due to inappropriate antidiuretic hormone (SIADH) secretion.
- The case study discusses a 56-year-old woman who experienced symptoms like blurry vision and headaches, ultimately diagnosed with euvolemic hyponatremia linked to RCC, which was treated effectively via endoscopic surgery.
- The article emphasizes the need for careful evaluation and a multidisciplinary approach in managing such rare instances, while calling for more research to enhance understanding and treatment strategies for RCC related to SIADH.
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