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Objective: A pathogenetic role of CD8+ T lymphocytes in radiographic axial spondyloarthritis (r-axSpA) and other spondyloarthritis (SpA) is sustained by genome-wide association studies (GWAS) and by the expansion of public T cell clonotypes in the target tissues. This study investigates the migration of CD8+ T cells, along with their phenotype and functions in patients with r-axSpA and psoriatic arthritis (PsA).

Methods: Peripheral blood CD8+ and CD4+ T cells were isolated from r-axSpA (n= 128), PsA (n= 60) and rheumatoid arthritis (RA, n= 74) patients and healthy donors (HD, n= 79).

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Spontaneous coronary artery dissection (SCAD) is a rare condition that frequently goes undiagnosed. Still, it is becoming an increasingly recognized cause of acute coronary syndrome (ACS), predominantly in middle-aged women with few or no cardiovascular risk factors. We present a case of a 53-year-old female with traditional cardiovascular risk factors, who presented with typical anginal symptoms and was diagnosed with SCAD in the mid to distal left anterior descending artery (LAD).

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Marfan syndrome: insights from animal models.

Front Genet

January 2025

Sichuan Provincial Key Laboratory for Genetic Disease, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

Marfan syndrome (MFS) is an inherited disorder that affects the connective tissues and mainly presents in the bones, eyes, and cardiovascular system, etc. Aortic pathology is the leading cause of death in patients with Marfan syndrome. The fibrillin-1 gene () is a major gene involved in the pathogenesis of MFS.

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Experience in the treatment of type C congenital esophageal atresia using a staged approach.

BMC Surg

January 2025

Department of Neonatal Surgery, National Center for Children's Health, Beijing Children Hospital, Capital Medical University, 56 Nanlishi Road, Beijing, 100045, China.

Background: In select patients with type C esophageal atresia, primary anastomosis is not appropriate and a staged approach is required. We aim to summarize our experience in the management of type C EA using a staged approach.

Methods: A retrospective chart-review of patients with type C EA admitted to Beijing Children's Hospital between July 2020 to October 2023 were conducted.

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Prevalence, risk factors, and adverse outcomes of bacterial vaginosis among pregnant women: a systematic review.

BMC Pregnancy Childbirth

January 2025

Department of Social Administration & Justice, Faculty of Arts & Social Sciences, Universiti Malaya, Kuala Lumpur, Asbah, Razali, 50603, Malaysia.

Introduction: Bacterial vaginosis (BV) is one of the most common genital tract infections among women of reproductive age. The existence of BV among pregnant women has momentously attracted the attention of both clinicians and the scientific community due to its potential link with adverse clinical outcomes in pregnancy.

Methods: To evaluate the prevalence, risk factors, and adverse outcomes of bacterial vaginosis among pregnant women, a comprehensive systematic review was conducted based on the preferred reporting items for systematic review and meta-analyses (PRISMA) criteria.

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