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Functional nanozyme system for synergistic tumor immunotherapy via cuproptosis and ferroptosis activation.
J Nanobiotechnology
March 2025
Fujian Key Laboratory of Flexible Electronics, Strait Laboratory of Flexible Electronics (SLoFE), Strait Institute of Flexible Electronics (SIFE, Future Technologies), Fujian Normal University, Fuzhou, Fujian, 350117, China.
Elevated copper levels induce tumor cuproptosis and ferroptosis, leading to immunogenic cell death and subsequent antitumor immune responses. However, dysregulated copper metabolism in tumor cells maintains homeostatic copper balance, while hypoxic microenvironments hinder therapeutic efficacy. In this study, we present a nanozyme system, termed CussOMEp, comprising a copper-based nanovector (CussNV) that is PEGylated and loaded with omeprazole, a copper transporter inhibitor, to enhance tumor synergistic immunotherapy by promoting cuproptosis and ferroptosis.
View Article and Find Full Text PDFMechanism of the GALNT family proteins in regulating tumorigenesis and development of lung cancer (Review).
Mol Clin Oncol
April 2025
Department of Cardiothoracic Surgery, Mingguang People's Hospital, Mingguang, Anhui 239400, P.R. China.
Lung cancer is one of the most common and lethal malignant tumors. Currently, surgical resection is the most effective treatment for early-stage lung cancer, and often results in favorable recovery outcomes. Therefore, early detection and control of lung cancer occurrence, invasion and metastasis are crucial for improving patient survival rates.
View Article and Find Full Text PDFCOVID-19 infection and pulmonary sarcoidosis: a systematic review and meta-analysis of morbidity, severity and mortality.
J Thorac Dis
February 2025
Division of Respiratory and Critical Care Medicine and Allergy, Korea University College of Medicine, Seoul, Republic of Korea.
Background: The pandemic coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) influenced millions of lives, not only healthy subjects but also patients with various comorbidities. Of those, interstitial lung disease (ILD) is known to be specifically vulnerable to SARS-CoV-2, sometimes leading to a lethal outcome. Sarcoidosis, one of the ILDs, has been suggested to be more susceptible to COVID-19, but the results of previous studies are in disagreement.
View Article and Find Full Text PDFRescue of loss-of-function long QT syndrome-associated mutations in K7.1/KCNE1 by the endocannabinoid N-arachidonoyl-L-serine (ARA-S).
Br J Pharmacol
March 2025
Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Background And Purpose: Congenital long QT syndrome (LQTS) involves genetic mutations affecting ion channels, leading to a prolonged QT interval and increased risk of potentially lethal ventricular arrhythmias. Mutations in the genes encoding K7.1/KCNE1 are the most frequent, with channel loss-of-function contributing to LQTS.
View Article and Find Full Text PDFLethal co-expression intolerance underlies the mutually exclusive expression of ASCL1 and NEUROD1 in SCLC cells.
NPJ Precis Oncol
March 2025
Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Small cell lung cancer (SCLC) subtypes, defined by the expression of lineage-specific transcription factors (TFs), are thought to be mutually exclusive, with intra-tumoral heterogeneities. This study investigated the mechanism underlying this phenomenon with the aim of identifying a novel vulnerability of SCLC. We profiled the expression status of ASCL1, NEUROD1, POU2F3, and YAP1 in 151 surgically obtained human SCLC samples.
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