A 1.5 cm long copper wire caused complete inhibition of fertility in male rats when placed properly in the vasal lumen. The contraceptive effectiveness of the device was directly proportional to the surface area of the device and was non-obstructive. The release rate of copper in vivo from a 1.5 cm long wire was 11.6 micrograms/day during the first month and 6.8 micrograms/day over the first 3 months. The contraceptive action of the wire starts about 20 days after insertion. Fertility was regained in 67% of the rats by 90 days after removal of the device. Similar devices of stainless steel and silver did not affect fertility.
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http://dx.doi.org/10.1530/jrf.0.0590341 | DOI Listing |
Resusc Plus
June 2024
Department of Anesthesia and Intensive Care Medicine, Oslo University Hospital, Oslo, Norway.
Aim: To determine whether targeting mild hypercapnia (PaCO 7 kPa) would yield improved cerebral blood flow and metabolism compared to normocapnia (PaCO 5 kPa) with and without targeted temperature management to 33 °C (TTM33) in a porcine post-cardiac arrest model.
Methods: 39 pigs were resuscitated after 10 minutes of cardiac arrest using cardiopulmonary bypass and randomised to TTM33 or no-TTM, and hypercapnia or normocapnia. TTM33 was managed with intravasal cooling.
Cell Mol Life Sci
December 2022
Program in Membrane Biology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Mononuclear phagocytes (MPs) play an active role in the immunological homeostasis of the urogenital tract. In the epididymis, a finely tuned balance between tolerance to antigenic sperm and immune activation is required to maintain epididymal function while protecting sperm against pathogens and stressors. We previously characterized a subset of resident MPs that express the CX3CR1 receptor, emphasizing their role in antigen sampling and processing during sperm maturation and storage in the murine epididymis.
View Article and Find Full Text PDFJ Antimicrob Chemother
February 2023
Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Background: High protein binding (PB) of antibiotics has an impact on their antimicrobial activity. It has been questioned whether in vitro PB determination can capture the dynamic and concentration-dependent PB of highly bound antibiotics.
Objectives: This clinical study compared in vitro ultrafiltration (UF) and in vivo IV microdialysis (MD) methods to determine ceftriaxone PB.
Andrologia
December 2022
Urology Department, Hamad Medical Corporation, Doha, Qatar.
Genitourinary anomalies constitute a large proportion of congenital malformations. However seminal tract anomalies, particularly ejaculatory duct (ED) anomalies are very rare and little information exists on the topic. We are reporting a very rare case of bilateral ectopic EDs opening in the bladder trigone in a 33-year-old gentleman presenting for evaluation for primary infertility.
View Article and Find Full Text PDFResuscitation
October 2021
Department of Anaesthesiology, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Aim: To determine whether targeting a mean arterial pressure of 90 mmHg (MAP90) would yield improved cerebral blood flow and less ischaemia compared to MAP 60 mmHg (MAP60) with and without targeted temperature management at 33 °C (TTM33) in a porcine post-cardiac arrest model.
Methods: After 10 min of cardiac arrest, 41 swine of either sex were resuscitated until return of spontaneous circulation (ROSC). They were randomised to TTM33 or no-TTM, and MAP60 or MAP90; yielding four groups.
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