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The nucleolin antagonist N6L and paclitaxel combination treatment could be a new promising therapeutic strategy for pancreatic ductal adenocarcinoma therapy.
Eur J Pharmacol
January 2025
Université Paris-Est, Immunorégulation et Biothérapie, INSERM U955, Hôpital Henri Mondor, 94010 Créteil, France; AP-HP, Groupe hospitalo-universitaire Chenevier Mondor, Centre d'investigation clinique Biotherapie, F-94010 Creteil, France. Electronic address:
Pancreatic cancer (PCa) is one of the most devastating cancers with few clinical signs and no truly effective therapy. In recent years, our team has demonstrated that nucleolin antagonists such as N6L could be a therapeutic alternative for this disease. In order to study a possible clinic development of N6L (multivalent pseudopeptide), we undertook to study the effect of combination of N6L with chemotherapies classically used for PCa on the survival of pancreatic cancer cells.
View Article and Find Full Text PDFMolecular miscibility of ASD blend components: an evaluation of (the added value of) solid state NMR spectroscopy and relaxometry.
J Pharm Sci
January 2025
Drug Delivery and Disposition, KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Campus Gasthuisberg ON2, Herestraat 49 b921, 3000 Leuven, Belgium. Electronic address:
In order to evaluate the stability of an amorphous solid dispersion (ASD) it is crucial to be able to accurately determine whether the ASD components are homogeneously mixed or not. Several solid-state analysis techniques are at the disposal of the formulation scientist, such as for example modulated differential scanning calorimetry (mDSC) and solid-state nuclear magnetic resonance spectroscopy (ssNMR). ssNMR is a robust, versatile, and accurate analysis technique with a large number of application possibilities.
View Article and Find Full Text PDFAssessing Nurses' Knowledge Regarding the Application of Artificial Intelligence Among Nursing Practice.
Nurs Res Pract
January 2025
Department of Statistics, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Unlabelled: Artificial intelligence (AI) is constantly improving the quality of medical procedures. Despite the application of AI in the healthcare industry, there are conflicting opinions among professionals, and limited research on its practical application in Saudi Arabia was conducted.
Aim: To assess the nurses' knowledge regarding the application of AI in practice at one of the Ministry of Health hospitals in Saudi Arabia.
Targeted barcoding of variable antibody domains and individual transcriptomes of the human B-cell repertoire using Link-Seq.
PNAS Nexus
January 2025
Institute of Bioengineering, School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
Here, we present Link-Seq, a highly efficient droplet microfluidic method for combined sequencing of antibody-encoding genes and the transcriptome of individual B cells at large scale. The method is based on 3' barcoding of the transcriptome and subsequent single-molecule PCR in droplets, which freely shift the barcode along specific gene regions, such as the antibody heavy- and light-chain genes. Using the immune repertoire of COVID-19 patients and healthy donors as a model system, we obtain up to 91.
View Article and Find Full Text PDFSynthesis of reusable cement materials through photochemical modification of marble powder for composite structures.
Heliyon
January 2025
Department of Physics, University of Okara, Okara, 56300, Pakistan.
Sustainability and environmental protection are reshaping industries, including construction, where sustainability plays a crucial role in its influence on global resource consumption and waste management. The current study has developed a reusable cement material by photo-chemical surface modification of marble powder, achieved by reacting glycidyl methacrylate with carbonate functionality. This innovative modified marble powder boosts the reusability of construction materials, unlocking new possibilities for sustainable building practices.
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