AI Article Synopsis
- A study on five dogs showed that as portal pressure increased from 6 to 42 mmHg, splanchnic blood flow decreased in a linear pattern.
- The absorption of ammonia, water, sodium, and chloride in four dogs was also negatively impacted by rising portal pressures, but this effect disappeared when normal pressure levels returned.
- It is proposed that creating a portasystemic shunt to relieve pressure may lead to increased blood flow to the mesentery and higher colonic ammonia absorption, potentially leading to issues like portasystemic encephalopathy.
Article Abstract
Splanchnic blood flow was studied over a wide range of portal pressures in five dogs. An inverse linear relationship between flow and pressure was found in the range from 6 to 42 mmHg. The colonic absorption of ammonia, water, sodium, potassium, bicarbonate, and chloride was measured in four dogs over a similar range of portal pressures. Absorption of ammonia, water, sodium, and chloride was significantly reduced by increasing portal pressure, and this reduction was abolished when portal pressure was allowed to return to the basal level. It is suggested that splanchnic decompression by portasystemic shunt gives rise to increased mesenteric flow and increased colonic ammonia absorption, which may contribute to portasystemic encephalopathy.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1419660 | PMC |
| http://dx.doi.org/10.1136/gut.21.6.475 | DOI Listing |
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