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Differentiation of glioblastoma G4 and two types of meningiomas using FTIR spectra and machine learning.

Anal Biochem

December 2024

Institute of Nuclear Physics, Polish Academy of Sciences, 31-342 Krakow, Poland; Department of Biochemistry and Molecular Biology, Medical University of Lublin, Lublin, Poland. Electronic address:

Brain tumors are among the most dangerous, due to their location in the organ that governs all life processes. Moreover, the high differentiation of these poses a challenge in diagnostics. Therefore, this study focused on the chemical differentiation of glioblastoma G4 (GBM) and two types of meningiomas (atypical - MAtyp and angiomatous - MAng) were done using Fourier Transform InfraRed (FTIR) spectroscopy, combined with statistical, multivariate, machine learning and rate of spectrum changes methods.

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Article Synopsis
  • - Neurodegenerative diseases, like Alzheimer's and Parkinson's, lead to neuron loss and significantly impact many lives, prompting the search for new therapies beyond current medications.
  • - Magnesium (Mg) is an essential mineral important for central nervous system health, but its specific role in human neurodegenerative diseases is not well understood.
  • - This review explores the connection between Mg levels and neurodegenerative disorders by analyzing biological samples from patients and animal model studies, suggesting that Mg may have neuroprotective properties; however, further research is needed for clarity on its therapeutic use.
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Article Synopsis
  • Aggressive pituitary neuroendocrine tumors (PitNETs) often grow despite treatment and can metastasize, making them particularly challenging to manage.
  • This study analyzed tumor samples from 64 patients to investigate genetic markers, finding distinct patterns between aggressive/metastatic tumors and benign ones through genome-wide methylation and chromosomal analyses.
  • The results indicate potential biomarkers that could help in identifying high-risk patients earlier, refining treatment protocols, and improving outcomes for those with aggressive pituitary tumors.
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[ improves cognitive decline in a rat model of Alzheimer's disease by regulating intestinal microorganisms].

Nan Fang Yi Ke Da Xue Xue Bao

July 2024

Sichuan-Chongqing Joint Key Laboratory of Innovation of New Drugs of Traditional Chinese Medicine, Chongqing Academy of Chinese Materia Medica, Chongqing 400065, China.

Objective: To investigate the effect of (YGS) on learning and memory abilities of rats with lipopolysaccharide (LPS)‑induced cognitive decline and explore its possible mechanism in light of intestinal microbiota.

Methods: Forty SD rats were randomly divided into control group, model group, donepezil (1.3 mg/kg) group, and high-dose (5.

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This study aimed to investigate the therapeutic effect of Shenfu Injection on mice with chronic heart failure(CHF) and its effect on macrophage polarization. C57BL/6J mice were randomly assigned to the normal and model groups. The CHF model was established by intraperitoneal injection of isoproterenol(ISO, 7.

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