During an outbreak of influenza in April, 1979, caused by A (H1N1) virus the protective effect of remantadine in combination with vaccinations using a national-made live A (H3N2) and inactivated A (H1N1) and B vaccines was studied. The best protective effect was achieved in the subjects vaccinated with influenza vaccines and given remantadine for urgent prophylaxis. Vaccination prophylaxis reduced the incidence of influenza and ARD 1.4-fold, prophylaxis with remantadine alone 2.3-fold.

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