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De novo designed proteins neutralize lethal snake venom toxins.
Nature
January 2025
Department of Biochemistry, University of Washington, Seattle, WA, USA.
Snakebite envenoming remains a devastating and neglected tropical disease, claiming over 100,000 lives annually and causing severe complications and long-lasting disabilities for many more. Three-finger toxins (3FTx) are highly toxic components of elapid snake venoms that can cause diverse pathologies, including severe tissue damage and inhibition of nicotinic acetylcholine receptors, resulting in life-threatening neurotoxicity. At present, the only available treatments for snakebites consist of polyclonal antibodies derived from the plasma of immunized animals, which have high cost and limited efficacy against 3FTxs.
View Article and Find Full Text PDFA novel method for the rapid determination of phenolic compounds based on the nanozyme with laccase-like activity.
Environ Res
January 2025
Key Laboratory of Groundwater Resources and Environment (Jilin University), Ministry of Education, College of New Energy and Environment, Jilin University, Changchun 130021, P. R. China; Jilin Provincial Key Laboratory of Water Resources and Water Environment, College of New Energy and Environment, Jilin University, Changchun 130021, P. R. China. Electronic address:
Phenolic compounds are prevalent in domestic and industrial effluents, leading a serious environmental hazard. Paper-based analysis device mediated by nanozymes has shown great potential in portable visual determination of phenolic compounds in the environment. In this work, we used nicotinic acid derivatives such as pyridine-2,3-dicarboxylic acid, 2-methylnicotinic acid and 2-aminonicotinic acid by coordinating copper (II) acetate monohydrate coordination to obtain Cu2-COOHNA, Cu2-CHNA, Cu2-ANA nanozymes with laccase-activity.
View Article and Find Full Text PDFSynthesis of harmaline N-9 derivatives and investigation of in vitro anticancer activity.
Bioorg Med Chem Lett
January 2025
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488 China. Electronic address:
Harmaline as a natural compound possessed a wide range of pharmacological activities. In this study, 22 novel harmaline-based derivatives were synthesized and screened for in vitro anti-proliferation activity against three cancer cell lines, HCT116, MCF7, and MGC803. The modification site was at the position N-9 of harmaline.
View Article and Find Full Text PDFMarine-derived bioactive compounds for neuropathic pain: pharmacology and therapeutic potential.
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar, Punjab, India.
Neuropathic pain, a challenging condition often associated with diabetes, trauma, or chemotherapy, impairs patients' quality of life. Current treatments often provide inconsistent relief and notable adverse effects, highlighting the urgent need for safer and more effective alternatives. This review investigates marine-derived bioactive compounds as potential novel therapies for neuropathic pain management.
View Article and Find Full Text PDFSynthesis, Structure and Biological Activity of 2-Methyl-5-nitro-6-phenylnicotinohydrazide-Based Hydrazones.
Molecules
January 2025
Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, 1 Alikhanov St., Karaganda 100008, Kazakhstan.
The synthetic availability and wide range of biological activity of hydrazides and hydrazones make them attractive subjects for investigation. In this study, we focused on synthesis of 2-methyl-5-nitro-6-phenylnicotinohydrazide-based hydrazones derived from the corresponding substituted aldehydes. The structure of the obtained compounds was studied using NMR spectroscopy and DFT calculations.
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