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A High-Throughput NMR Method for Lipoprotein-X Quantification.
Molecules
January 2024
Labcorp, Morrisville, NC 27560, USA.
Lipoprotein X (LP-X) is an abnormal cholesterol-rich lipoprotein particle that accumulates in patients with cholestatic liver disease and familial lecithin-cholesterol acyltransferase deficiency (FLD). Because there are no high-throughput diagnostic tests for its detection, a proton nuclear magnetic resonance (NMR) spectroscopy-based method was developed for use on a clinical NMR analyzer commonly used for the quantification of lipoproteins and other cardiovascular biomarkers. The LP-X assay was linear from 89 to 1615 mg/dL (cholesterol units) and had a functional sensitivity of 44 mg/dL.
View Article and Find Full Text PDFIn Vitro and In Silico Screening and Characterization of Antimicrobial Napin Bioactive Protein in and .
Molecules
April 2021
Department of Food Science and Biotechnology, College of Agriculture and Life Science, Kangwon National University, Chuncheon 24341, Korea.
The study aimed to investigate the antibacterial activity of Mustard () and Moringa () leaf extracts and coagulant protein for their potential application in water treatment. Bacterial cell aggregation and growth kinetics studies were employed for thirteen bacterial strains with different concentrations of leaf extracts and coagulant protein. leaf extract (MOS) and coagulant protein showed cell aggregation against ten bacterial strains, whereas leaf extract alone showed growth inhibition of five bacterial strains for up to 6 h and five bacterial strains for up to 3 h.
View Article and Find Full Text PDFLipoprotein-X in cholestatic patients causes xanthomas and promotes foam cell formation in human macrophages.
J Clin Lipidol
October 2017
Department of Clinical Laboratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan. Electronic address:
Background: Lipoprotein-X (Lp-X) is an abnormal phospholipid-rich lipoprotein found in patients with cholestatic liver disease. Some patients exhibit skin xanthomas and severe hyperlipidemia.
Objective: We investigated whether Lp-X induces foam cell formation in human-derived macrophages.
The LDL-C level measures with homogeneous (direct) assays in almost of clinical laboratories. Several reports however showed differences in measured values among the assay reagents. We investigated the differences in LDL-C values among direct assays and Friedewald formula (F-f) in 58 LP-X positive serum samples from jaundice patients by comparing LDL-C values measured by anion-exchange chromatography (AEX-HPLC), largely comparable to ultracentrifugation method.
View Article and Find Full Text PDFSevere hypercholesterolemia in patients with graft-vs-host disease affecting the liver after stem cell transplantation.
Endocr Pract
June 2012
Department of Diabetes, Endocrinology, and Metabolism, City of Hope National Medical Center, Duarte, California 91010, USA.
Objective: To review the available literature on severe hypercholesterolemia occurring in the context of graft-vs-host disease affecting the liver.
Methods: A literature search was conducted in PubMed for articles on hypercholesterolemia occurring in the context of graft-vs-host disease after allogeneic hematopoietic stem cell transplantation. The review included the type of lipid abnormalities observed, complications, and available management strategies.
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