The authors propose a structure of controlled accessory systems that are intended to substitute the functions of different human organs. It is shown, that during controlled process it is possible to extract the value indicating the variability of the substituted organ activity and to use it as the control criterion.
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Anal Chem
January 2025
Key Laboratory of Advanced Materials of Tropical Island Resources of Ministry of Education, School of Chemistry and Chemical Engineering, Hainan University, Haikou 570228, China.
As the third largest class of dyes in the world, triphenylmethane dyes are widely applied in colorimetric sensing. However, triphenylmethane dyes are commonly nonfluorescent, which limits their sensing applications. It is worthwhile to study the fluorescence off/on control of triphenylmethane dyes and promote the applications of triphenylmethane dyes in sensing technology.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Community Medicine and School of Public Health, Post-Graduate Institute of Medical Education and Research, Chandigarh, India.
Background: Technological advancements and globalization have shifted dietary behaviours, contributing to increased chronic disease prevalence in Low- and Middle-Income Countries (LMICs) like India. Adolescents are particularly vulnerable due to these changes, which can impact their lifelong health. This study aimed to assess the nutritional status of adolescents in public schools in Chandigarh, India.
View Article and Find Full Text PDFPLoS Pathog
January 2025
LPHI, UMR 5294 CNRS/UM-UA15 Inserm, Université de Montpellier, Montpellier, France.
A sustained blood-stage infection of the human malaria parasite P. falciparum relies on the active exit of merozoites from their host erythrocytes. During this process, named egress, the infected red blood cell undergoes sequential morphological events: the rounding-up of the surrounding parasitophorous vacuole, the disruption of the vacuole membrane and finally the rupture of the red blood cell membrane.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2025
East China University of Science and Technology, School of Chemistry and Molecular Engineering, Meilong Road 130, 200237, Shanghai, CHINA.
Kinetically controlled self-assembly is garnering increasing interest in the field of supramolecular polymers and materials, yet examples involving dynamic covalent exchange remain relatively unexplored. Here we report an unexpected dynamic covalent polymeric system whose aqueous self-assembly pathway is strongly influenced by the kinetics of evaporation of water. The key design is to integrate dual dynamic covalent bonds-including disulfide bonds and boroxine/borate-into a dynamic equilibrium system of monomers, polymers, and materials.
View Article and Find Full Text PDFCRISPR J
January 2025
Department of Animal Science, University of California, Davis, California, USA.
In mice, naturally occurring and induced mutations in the suppressor of cytokine signaling-2 () gene are associated with a high growth phenotype characterized by rapid post-weaning weight gain and 30-50% heavier mature body weight. In this work, we demonstrate an electroporation-based method of producing knock-out (KO) sheep. Electroporation of dual-guide CRISPR-Cas9 ribonucleoprotein complexes targeting was performed 6 h post-fertilization in sheep zygotes.
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