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Paraneoplastic production of human chorionic gonadotropin by paratesticular dedifferentiated liposarcoma with rhabdomyosarcomatous differentiation.
BMJ Case Rep
August 2024
Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Article Synopsis
- - A man in his 70s was diagnosed with a large left inguinoscrotal mass, and tests revealed extremely high levels of hCG, leading to the identification of paratesticular dedifferentiated liposarcoma (DDLPS) with rhabdomyosarcomatous features after surgical resection.
- - The patient unfortunately passed away 11 months later due to distant metastasis, highlighting that hCG-producing soft tissue sarcomas (STS) are typically aggressive, poorly differentiated, and associated with a poor prognosis.
- - This case emphasizes the need for more research on the treatment of DDLPS, particularly the potential benefits of adjuvant radiotherapy, given the rapid growth and
Ectopic production of beta-hCG in anal cancer: A case report.
Clin Case Rep
March 2024
Cowell Cancer Center, Munson Healthcare Foundation Traverse City Michigan USA.
Key Clinical Message: Beta-hCG-producing anal cancer, though rare, poses significant diagnostic challenges and may resist standard therapies. Recognizing the potential for hormone production in anal cancer is important, as it underscores the need for more specialized diagnostic techniques and tailored treatments.
Abstract: This case report describes the second reported case of ectopic production of beta-hCG in anal cancer.
Case Report: Complete pathological remission of human chorionic gonadotrophin-producing gallbladder carcinoma with multiple liver metastases after treatment with chemotherapy plus an immune checkpoint inhibitor.
Front Immunol
October 2023
Department of Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Background: Gallbladder carcinoma (GBC) producing human chorionic gonadotrophin (HCG) is an extremely rare and highly invasive tumor with a poor prognosis. This unfavorable clinical outcome is partly due to the aggressive nature of the tumor and its insensitivity to chemotherapy.
Case Presentation: We herein report a case of primary GBC producing HCG with liver metastases in a 58-year-old woman.
We present the case of a 54-year-old woman diagnosed with uterine leiomyosarcoma that produced beta-human chorionic gonadotropin (β-hCG), evident by both serum and immunohistologic examination. Based on this and similar cases from the available literature, β-hCG-producing sarcomas tend to have poorer prognosis, indicating that β-hCG could potentially be used as a marker of disease status and response to the therapy; however, this association is inconsistent and should be further investigated.
View Article and Find Full Text PDFBeta-human chorionic gonadotropin-producing neuroblastoma: an unrecognized cause of gonadotropin-independent precocious puberty.
Endocr J
March 2022
Department of Gastroenterology, Nutrition, and Endocrinology, Osaka Women's and Children's Hospital, Osaka 594-1101, Japan.
The pathogenesis of gonadotropin-independent precocious puberty (PP) includes both congenital and acquired forms, the latter of which may be associated with neoplasms, such as sex-steroid hormone-producing tumors. Beta-human chorionic gonadotropin (β-hCG)-producing tumors also cause gonadotropin-independent PP by stimulating the production of testosterone in Leydig cells. Germ cell tumors and hepatoblastoma both produce β-hCG; however, there is limited evidence to show that gonadotropin-independent PP is caused by other β-hCG-producing tumors.
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