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A health economic analysis of noninjectable epinephrine compared with intramuscular epinephrine.
Ann Allergy Asthma Immunol
December 2024
Section of Allergy and Immunology, Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado.
Background: Noninjectable epinephrine to treat allergic reactions addresses an unmet need. Intranasal epinephrine is approved and a sublingual form is under development. Inhaled epinephrine is poorly studied for anaphylaxis.
View Article and Find Full Text PDFEpigenetic mechanisms of alveolar macrophage activation in chemical-induced acute lung injury.
Front Immunol
November 2024
Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Article Synopsis
- Airways and alveoli are particularly susceptible to toxic chemical exposure, but the lungs have effective protective mechanisms to maintain function.
- Alveolar macrophages act as the primary defense by combating pathogens and harmful substances that penetrate the airway barrier.
- Recent studies are focusing on alveolar macrophages as therapeutic targets to understand their role in disease development, especially concerning chemical-induced acute lung injury.
Prophylactic Systemic Antibiotic and Systemic Glucocorticoid Therapy After Burn Inhalation Injury: A Report of Two Cases and Review of Literature.
Cureus
August 2024
Respiratory and Critical Care Medicine, The Third Affiliated Hospital of Southern Medical University, Guangzhou, CHN.
Burn inhalation injury is a significant risk factor for mortality in burn patients. Despite the considerable progress made in the treatment of burn inhalation injury, there remains no consensus on the appropriate course of treatment, leading to ongoing controversy regarding the use of prophylactic systemic antibiotics and systemic glucocorticoids. This study presents two cases of burn inhalation injury diagnosed by fiberoptic bronchoscopy and treated with systemic glucocorticoids and prophylactic systemic antibiotics.
View Article and Find Full Text PDFPostmortem or Perimortem Injury? Presentation of an incredible court case in which flames are the protagonists of a murder.
Clin Ter
July 2024
Section of Legal Medicine, Department of Interdisciplinary Medicine, University of Bari, Bari, Italy.
Background: Establishing the cause of death when analysing burnt human remains is limiting due to thermal degradation. The heat generated by high combustion degrades the bone structure, definitively hiding the perimortem trauma in most cases, which is crucial for solving a court case.
Case Report: In November 2019, a completely burnt corpse was found inside a car set on fire near a location in Reggio Calabria, Italy.
Analysis of Patients Admitted for Asthma Exacerbation in a Tertiary Hospital in Spain.
Cureus
June 2024
Pulmonology, Hospital Universitario San Juan de Alicante, Alicante, ESP.
Objectives: To analyze the characteristics of adult patients admitted for asthma exacerbation and determine optimization, treatment adherence, and follow-up in clinics.
Methods: Patients ≥ 18 years old admitted from May 2021 to June 2023 with a primary diagnosis of asthma exacerbation were included. Patients with a secondary diagnosis of asthma exacerbation and those without a confirmed diagnosis were excluded.
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