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Long-term blood-free rearing of Anopheles mosquitoes with no effect on fitness, Plasmodium infectivity nor microbiota composition.
Sci Rep
August 2024
Global Health and Tropical Medicine, GHTM, Associate Laboratory in Translation and Innovation Towards Global Health, LA-REAL, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, IHMT-NOVA, Rua da Junqueira 100, 1349-008, Lisboa, Portugal.
Article Synopsis
- Mosquito-borne diseases cause millions of deaths annually, prompting the need for new research and population control strategies that often require large-scale mosquito production.
- Traditional mosquito rearing methods depend heavily on fresh blood from humans or animals, creating ethical and financial challenges, especially due to the high volume needed.
- The BLOODless diet, a patented development, allows for sustainable long-term breeding of Anopheles stephensi mosquitoes in captivity without relying on blood, showing no negative effects on their health or infectivity over 40 generations.
Infectivity of Plasmodium parasites to Aedes aegypti and Anopheles stephensi mosquitoes maintained on blood-free meals of SkitoSnack.
Parasit Vectors
July 2024
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.
Background: Aedes and Anopheles mosquitoes are responsible for tremendous global health burdens from their transmission of pathogens causing malaria, lymphatic filariasis, dengue, and yellow fever. Innovative vector control strategies will help to reduce the prevalence of these diseases. Mass rearing of mosquitoes for research and support of these strategies presently depends on meals of vertebrate blood, which is subject to acquisition, handling, and storage issues.
View Article and Find Full Text PDFEffects of a blood-free mosquito diet on fitness and gonotrophic cycle parameters of laboratory reared Anopheles gambiae sensu stricto.
Parasit Vectors
July 2024
Environmental Health and Ecological Science Department, Ifakara Health Institute-Bagamoyo Office, P.O. Box 74, Bagamoyo, Tanzania.
Background: The current rise of new innovative tools for mosquito control, such as the release of transgenic mosquitoes carrying a dominant lethal gene and Wolbachia-based strategies, necessitates a massive production of mosquitoes in the insectary. However, currently laboratory rearing depends on vertebrate blood for egg production and maintenance. This practice raises ethical concerns, incurs logistical and cost limitations, and entails potential risk associated with pathogen transmission and blood storage.
View Article and Find Full Text PDFHow an appreciation of dynamics has altered our understanding of the HPA axis.
Stress
January 2024
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Translational Health Sciences, Faculty of Health Sciences, University of Bristol, Bristol, UK.
Rhythmicity is a intrinsic feature of biological systems, including the hypothalamic-pituitary-adrenal axis, a mammalian neurohormonal system crucial both in daily life and as a network that responds to stressful stimuli. Circadian and ultradian rhythmicity underlie HPA activity in rodents and in humans, regulating gene expression, metabolism and behavior, and adverse consequences occur when rhythms are disturbed. In the assessment of human disease, the complexity of HPA rhythmicity is rarely acknowledged or understood, and is currently a limitation to better diagnosis and treatment.
View Article and Find Full Text PDFUse of FGF21 analogs for the treatment of metabolic disorders: a systematic review and meta-analysis.
Arch Endocrinol Metab
November 2023
Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
FGF21 is a hormone produced primarily by the liver with several metabolic functions, such as induction of heat production, control of glucose homeostasis, and regulation of blood lipid levels. Due to these actions, several laboratories have developed FGF21 analogs to treat patients with metabolic disorders such as obesity and diabetes. Here, we performed a systematic review and meta-analysis of randomized controlled trials that used FGF21 analogs and analyzed metabolic outcomes.
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