The mechanism of integration of osmo- and volume-regulating systems after intake of 3, 5, 7, and 10% of body weight water, salt, and volume loads, was studied in adult rats. The changes of diuretic and ionuretic renal functions depended on the character and quantity of shifts caused in organism. The volume shift is the starting mechanism for stabilization of disturbed balance while the osmotic factor secures the final regulation of watersalt homeostasis.
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