The immune response of the body to different clones of nasal staphylococcal population in polypous rhinosinusitis has been studied. The titers of antibodies to different staphylococcal clones were shown to differ considerably. The titers of antibodies to different clones in polypous tissue were found to be higher or lower than the respective titers in the general blood stream. Thus different immunologic conditions for the development of microorganisms could locally appear in the presence of intensive general immune reaction. This seems to be due to differences in the intensity of the production of antibodies to these microorganisms in the lymphoid tissue of the nasal mucosa.

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