Severity: Warning
Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 176
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3122
Function: getPubMedXML
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
Catecholamines and cortisol in blood were studied in 91 lung cancer patients and in 11 patients with benign neoplasms in the lung. The investigation peformed has shown a certain dependence between the process stage and the sympatho-adrenal system functioning. Total amount of catecholamines is increased as the disease progresses, reaching the maximum at stage III and is sharply decreased at stage IV. A correlation between adrenaline and noradrenaline is changed in favour of a relative predominance of the adrenal link in the sympatho-adrenal system. The cortisol level during the malignant tumor growth is changed in an undular fashion and is mostly raised in patients with stage I and II. The development of metastases is associated with some tendency toward raising catecholamines level and lowering the functional activity of the adrenal cortex.
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