Under similar conditions observations were performed in 157 humans: 9 patients with secondary defects of the interatrial septum (DIS-II), 122 patients within 1-15 years after surgery for the defect in question and 26 healthy humans. In addition to the known disturbances in hemodynamics of the small circulation circle accompanying DIS-II there were also disorders in the large blood circulation circle and respiration. The disorders were most pronounced under physical exercise. After operation the hemodynamics was found to be almost normal. The pattern of response to physical exercise in most operated patients was in full conformity with that of healthy people.
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