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[Research progress on pollen monitoring and pollen allergenicity of ragweed].
Zhonghua Yu Fang Yi Xue Za Zhi
December 2024
Department of Allergy, ShengJing Hospital of China Medical Universty, Shenyang110000, China.
Ragweed, as an exotic invasive species, which is one of the most important allergens for hay fever, has been invading China for more than 80 years. The increasing number of people with hay fever makes effective treatment, as well as the prevention and control of pollen transmission critical. This article delves into a comprehensive research summary focusing on the allergenic properties of ragweed pollen, its pathogenic characteristics, epidemiological patterns, monitoring and control measures, as well as concentrated management approaches.
View Article and Find Full Text PDFRole of PD-1/PD-L1 signaling axis in oncogenesis and its targeting by bioactive natural compounds for cancer immunotherapy.
Mil Med Res
December 2024
Department of Pharmacology, College of Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, FL, 34211, USA.
Cancer is a global health problem and one of the leading causes of mortality. Immune checkpoint inhibitors have revolutionized the field of oncology, emerging as a powerful treatment strategy. A key pathway that has garnered considerable attention is programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1).
View Article and Find Full Text PDFHealth-Related Quality of Life in Women With Metastatic Breast Cancer: An Integrative Review.
J Adv Nurs
November 2024
School of Nursing, Yale University, Orange, Connecticut, USA.
Article Synopsis
- The study aimed to analyze the health-related quality of life in women with metastatic breast cancer, focusing on factors influencing their experience over the last decade.
- An integrative review was conducted, screening 7,316 articles and selecting 25 studies that primarily involved non-Hispanic white women from the U.S. and Europe, using various assessment tools.
- Key findings indicated that physical and psychological symptoms significantly impact quality of life, highlighting the need for better symptom management and more diverse research to understand the effects of new therapies.
[Setting up haploidentical hematopoietic cell transplantation in low- and middle-income countries: The Recommendations of the Francophone Society of Bone Marrow and Cellular Therapy (SFGM-TC)].
Bull Cancer
January 2025
Service d'hématologie et de thérapie cellulaire, établissement hospitalier universitaire 1er Novembre d'Oran, université Ahmed Benbella 1, Oran, Algérie.
Article Synopsis
- Haploidentical hematopoietic cell transplantation (haplo-HCT) is increasingly used globally but remains uncommon in low- and middle-income countries, prompting a working group from the SFGM-TC to propose recommendations for implementation.
- * The potential advantages of haplo-HCT include better accessibility to donors and lower costs; however, it should only be performed in experienced centers with a track record of related HLA-matched transplants.
- * Regular evaluations are necessary to monitor the feasibility and outcomes of implementing haplo-HCT in these regions, particularly for patients lacking HLA-matched donors.*
Cancer Immunotherapy Trials Network 12: Pembrolizumab in HIV-Associated Kaposi Sarcoma.
J Clin Oncol
October 2024
HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Article Synopsis
- The Cancer Immunotherapy Trials Network 12 study showed that pembrolizumab is safe and effective for treating advanced Kaposi sarcoma (KS) in people with HIV on antiretroviral therapy.
- In a phase I trial involving 32 participants, 62.1% had a positive response to pembrolizumab, with even higher rates (87.5%) for those who hadn't received previous KS treatments.
- The treatment led to significant progression-free survival, with a median of 28.2 months, and immune-mediated adverse events were effectively managed according to established guidelines.
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