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Structural modelling and pharmacology of β-carboline alkaloids as potent 5-HT1A receptor antagonists and reuptake inhibitors.
J Biomol Struct Dyn
July 2023
Centre for Drug Research, Universiti Sains Malaysia, USM, Pulau Pinang, Malaysia.
Serotonin (5-HT) antagonists and reuptake inhibitors (SARIs) are atypical antidepressants for managing major depressive disorder. They are oftentimes applied as adjuvants for ameliorating aftereffects of SSRI antidepressants including insomnia and sexual dysfunction. The few available candidates of this class including lorpiprazole and trazodone also display some daunting side effects, making a continuous search for improved alternatives essential.
View Article and Find Full Text PDFAlleviation of the Genotoxic Effect of Experimental Circulatory Brain Hypoxia in Rat Cornea under the Effect of Infrared Low-Level Laser Radiation.
Bull Exp Biol Med
March 2022
I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
Experimental modeling of oxidative stress was conducted by creating circulatory brain hypoxia, accompanied by development of free radical processes leading to genome instability through an example of anterior epithelial layer of rat cornea. We studied the influence of infrared low-level laser radiation (ILLLR) in the therapeutic dose and mode (pulse power 8 W, λ=0.89 μm).
View Article and Find Full Text PDFEpigenetic phenomena are defined as morpho-physiological changes not related to impairments of DNA sequence. The results of our study indicate that a pulsed non-mutagenic thermal stress inflicted on developing ova (pro-embryos) gives rise to positive transgenerational epigenetic changes in the life span of offspring. At that, this effect depends on heterozygosity by lgl-mutation inherited from mothers.
View Article and Find Full Text PDFA nonstochastic heritable cell lethality effect was for the first time used in the practice of biotesting in a model of Saccharomyces yeasts for predicting the hazard of low mutagen doses. It was demonstrated that the heritable cell lethality might be induced by multicomponent mutagens of a technogenic nature, for example, sewage waters of gas-transferring plants. The possibility of extrapolation of the results to multicellular organisms is discussed.
View Article and Find Full Text PDF[Treatment of hemorrhagic cystitis secondary to cyclophosphamide. Literature review with regard to a case].
Actas Urol Esp
February 2005
Servicio de Urología, Hospital Universiario Miguel Servet, Zaragoza.
There are extreme situations in the clinical treatment of intractable hematuria (fortunately not a common disease nowadays), in which even benign process may represent a serious risk to the life of the patient and where certain aggressive procedures like cystectomy have to be considered. Our objective in this paper is to review the different existing therapeutic alternatives for the treatment of an intense type of hematuria which does not yield to continuous saline serum irrigation. This study is partly based on a recent real clinical case in which, after the administration of cyclophosphamide to a young patient with recurrent and intense hematuria, the excretion was controlled through intravesical alum irrigation of thus avoiding cystectomy, a very aggressive surgical procedure with many after-effects.
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