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Mechanical Abnormalities of the Airway Wall in Adult Mice After Intrauterine Growth Restriction.
Front Physiol
August 2019
School of Human Sciences, University of Western Australia, Perth, WA, Australia.
Developmental abnormalities of airways may impact susceptibility to asthma in later life. We used a maternal hypoxia-induced mouse model of intrauterine growth restriction (IUGR) to examine changes in mechanical properties of the airway wall. Pregnant BALB/c mice were housed under hypoxic conditions (10.
View Article and Find Full Text PDFPredictors of increased PaCO2 during immersed prone exercise at 4.7 ATA.
J Appl Physiol (1985)
January 2009
Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA.
During diving, arterial Pco(2) (Pa(CO(2))) levels can increase and contribute to psychomotor impairment and unconsciousness. This study was designed to investigate the effects of the hypercapnic ventilatory response (HCVR), exercise, inspired Po(2), and externally applied transrespiratory pressure (P(tr)) on Pa(CO(2)) during immersed prone exercise in subjects breathing oxygen-nitrogen mixes at 4.7 ATA.
View Article and Find Full Text PDFRecurrent milk aspiration produces changes in airway mechanics, lung eosinophilia, and goblet cell hyperplasia in a murine model.
Pediatr Res
December 2000
Department of Pediatrics, Section of Pediatric Pulmonology, Baylor College of Medicine, Houston, Texas 77030, USA.
Recurrent aspiration of milk into the respiratory tract has been implicated in the pathogenesis of a variety of inflammatory lung disorders including asthma. However, the lack of animal models of aspiration-induced lung injury has limited our knowledge of the pathophysiological characteristics of this disorder. This study was designed to evaluate the effects of recurrent milk aspiration on airway mechanics and lung cells in a murine model.
View Article and Find Full Text PDFRigid external resistances cause effort dependent maximal expiratory and inspiratory flows.
Am J Respir Crit Care Med
November 1995
Department of Pneumology, University Hospital Gasthuisberg, Leuven, Belgium.
A fixed orifice or a fixed upper airway obstruction (UAO) causes an expiratory and inspiratory plateau-shaped limitation on maximal flow-volume (MEFV, MIFV) curves and, according to the classic concept, a MEF50/MIF50 ratio of 0.9-1.1.
View Article and Find Full Text PDFStatic lung load and posture effects on pulmonary mechanics and comfort in underwater exercise.
Undersea Biomed Res
March 1992
Department of Preventive Medicine, University of Wisconsin-Madison 53705.
Static lung load (SLL), or transrespiratory pressure gradient, imposed by underwater breathing apparatus can affect breathing comfort and mechanics, especially during exertion. We examined the effects of body position and SLL on two factors known to affect or limit exertion: a) tidal flow-volume limitation, i.e.
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