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Novel Selectable Marker Sesquiterpenoid Antibiotic Pentalenolactone.
Int J Mol Sci
December 2024
Center for Molecular and Cellular Biology, 121205 Moscow, Russia.
Antibiotic resistance has been and remains a major problem in our society. The main solution to this problem is to search and study the mechanisms of antibiotic action. Many groups of secondary metabolites, including antimicrobial ones, are produced by the phylum.
View Article and Find Full Text PDFRestoring Multidrug-Resistant Sensitivity to Ampicillin in Combination with (-)-Epigallocatechin Gallate.
Antibiotics (Basel)
December 2024
Division of Microbiology and Parasitology, School of Medical Sciences, University of Phayao, Phayao 56000, Thailand.
Multidrug-resistant (MDR) bacteria, especially , are a major contributor to healthcare-associated infections globally, posing significant treatment challenges. This study explores the efficacy of (-)-epigallocatechin gallate (EGCG), a natural constituent of green tea, in combination with ampicillin (AMP) to restore the effectiveness of AMP against 40 isolated MDR strains. Antimicrobial activity assays were conducted to determine the minimum inhibitory concentrations (MIC) of EGCG using the standard microdilution technique.
View Article and Find Full Text PDFThe expression of different gene constructs in Escherichia coli SM lux biosensor after exposure to drugs.
Sci Rep
December 2024
Department of Agri-Food Engineering and Environmental Management, Bialystok University of Technology, 15-351, Białystok, Poland.
The research used bacterial biosensors containing bacterial luciferase genes to monitor changes in the environment in real-time. In this work to express four different gene constructs: recA:luxCDABE, soxS:luxCDABE, micF:luxCDABE, and rpoB:luxCDABE in Escherichia coli SM lux biosensor after exposure to three different antibiotics (nalidixic acid, ampicillin, kanamycin) and diclofenac was determined. It was found that incubation of the E.
View Article and Find Full Text PDFA mechanistic approach to optimize combination antibiotic therapy.
Biosystems
December 2024
Department of Pharmacy, UiT - the Arctic University of Norway, Tromsø, Norway; Department of Biology, Pennsylvania State University, University Park, PA, USA; Department of Digital Health Sciences and Biomedicine, University of Siegen, Siegen, Germany; Bioinformatics and Modelling, Norwegian Institute of Public Health, Oslo, Norway. Electronic address:
Antimicrobial resistance is one of the most significant healthcare challenges of our times. Multidrug or combination therapies are sometimes required to treat severe infections; for example, the current protocols to treat pulmonary tuberculosis combine several antibiotics. However, combination therapy is usually based on lengthy empirical trials, and it is difficult to predict its efficacy.
View Article and Find Full Text PDFβ-lactam antibiotics induce metabolic perturbations linked to ROS generation leads to bacterial impairment.
Front Microbiol
December 2024
College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China.
Understanding the impact of antibiotics on bacterial metabolism is crucial for elucidating their mechanisms of action and developing more effective therapeutic strategies. β-lactam antibiotics, distinguished by their distinctive β-lactam ring structure, are widely used as antimicrobial agents. This study investigates the global metabolic alterations induced by three β-lactam antibiotics-meropenem (a carbapenem), ampicillin (a penicillin), and ceftazidime (a cephalosporin)-in .
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