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Combined dimercaptosuccinic acid and zinc treatment in neurological Wilson's disease patients with penicillamine-induced allergy or early neurological deterioration.
Biosci Rep
August 2020
Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
The clinical data of safety and efficacy of a combined treatment with dimercaptosuccinic acid (DMSA) and Zinc with 2 years' follow-up in 60 neurological Wilson's disease (WD) patients was retrospectively analyzed. All the patients included in the present study were newly diagnosed and initialized with D-penicillamine (DPA) treatment but were found to have either neurological deterioration or allergy, and their treatment was switched to a combined treatment of DMSA and Zinc. Fifty-one patients (85%) had the neurological symptoms improved 1 and 2 years after treatment, 7 (11.
View Article and Find Full Text PDFEvaluation and Medical Management of Patients with Cystine Nephrolithiasis: A Consensus Statement.
J Endourol
November 2020
UC San Diego Health, San Diego, California, USA.
Cystinuria is a genetic disorder with both autosomal recessive and incompletely dominant inheritance. The disorder disrupts cystine and other dibasic amino acid transport in proximal tubules of the kidney, resulting in recurrent kidney stone formation. Currently, there are no consensus guidelines on evaluation and management of this disease.
View Article and Find Full Text PDFLiver transplantation for Wilson's disease: a single-center experience.
Liver Transpl Surg
November 1999
Division of Transplantation Surgery, University of New Mexico, Albuquerque, NM, USA.
Wilson's disease is a hereditary defect in copper excretion leading to the accumulation of copper in the tissues, with subsequent tissue damage. The most serious sequela is that of progressive central nervous system involvement. The use of orthotopic liver transplantation (OLT) has been controversial for those patients with neurological symptoms attributed to Wilson's disease.
View Article and Find Full Text PDF[Wilson's disease ("hepatic form") in a region endemic for schistosomiasis mansoni: clinical presentation of 25 patients].
Arq Gastroenterol
November 1998
Serviço de Gastroenterologia, Hospital Felício Rocho, Belo Horizonte, Brasil.
Brazil has a young population and areas of endemic mansoni schistosomiasis where Wilson's disease might be easily misdiagnosed in patients erroneously classified as having either the hepatosplenic or the hepatointestinal form of the helminthiasis. Twenty five patients with the "hepatic form" of Wilson's disease (14 males and 11 females) were investigated in Belo Horizonte, MG; the mean age was 13.7 years (3 to 22).
View Article and Find Full Text PDFBasal release of nitric oxide induces an oscillatory motor pattern in canine colon.
J Physiol
March 1997
Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno 89557, USA.
1. The consequences of intrinsic, basal nitric oxide release on electrical and contractile activity of canine proximal colon were examined. Membrane potential and contraction were simultaneously recorded from the circular muscle in the presence of drugs to block adrenergic and cholinergic responses.
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