Some of the 28 investigated new derivatives show distinct anticholinergic activity. The greatest activity, that of 2-cyclohexyl-2-phenyl-5-piperidinodioxane-1,3 was greater than of the atropine sulfate.
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Rheumatol Int
January 2025
School of Medicine, The University of Western Australia, 35 Stirling Highway, Perth, WA, 6009, Australia.
This study aims to review the literature and estimate the global pooled prevalence of interstitial lung disease among patients with rheumatoid arthritis (RA-ILD). The influence of risk factors like geography, socioeconomic status, smoking and DMARD use will be explored. A systematic review was performed according to the PRISMA and JBI guidelines.
View Article and Find Full Text PDFInt J Ment Health Syst
January 2025
University of Bordeaux, National Institute for Health and Medical Research (INSERM) UMR 1219, Research Institute for Sustainable Development (IRD) EMR 271, Bordeaux Population Health Centre, Bordeaux, France.
Introduction: Group Interpersonal Therapy (IPT), an evidence-based treatment of depression recommended by the WHO mhGAP Intervention Guide, was implemented through a task-shifting approach in Senegal, as a treatment for depressed people living with HIV (PLWH). Since a description of the resources used and the implementation costs incurred is necessary to inform policymakers better, this study aimed to estimate the costs associated with its implementation.
Methods: Intervention costs were analyzed using an "ingredients-based costing approach" from the provider's perspective.
BMC Oral Health
January 2025
Facultad de Odontología, Universidad de los Andes, Chile, Las Condes, Chile.
Introduction: Certain aspects of indigenous communities, such as cultural practices and access to care, have been discussed as potential determinants of oral health. However, research on this topic remains limited. Understanding the factors influencing oral health and their perceptions is crucial for developing culturally appropriate interventions.
View Article and Find Full Text PDFActa Neurol Belg
January 2025
Department of Pediatrics, Neurology Unit, University of Health Sciences, Ankara Etlik City Hospital, Ankara, Turkey.
Introduction: Zellweger spectrum disorder (ZSD) refers to a group of autosomal recessive genetic disorders that affect multiple organ systems and are predominantly caused by pathogenic variants in PEX genes. ZSD present a wide clinical spectrum, ranging from the most severe form, Zellweger syndrome, to the mildest form, Heimler syndrome.
Case Report: A 14-month-old male patient was brought to our clinic with recent-onset ocular tremors and unsteady gait.
Clin Rheumatol
January 2025
Department of Dentistry-Division of Oral Medicine, Oral Pathology and Radiology, and Division of Dental Hygiene, Faculty of Medicine and Dentistry, University of Alberta, Room 5-357 Edmonton Clinic Health Academy, 11405 87 Avenue NW, Edmonton, AB, Canada.
Introduction: Sjögren's syndrome (SS) presents complex diagnostic challenges due to its multi-organ involvement, often leading to misdiagnosis, which can result in unnecessary treatments, elevated healthcare costs, and significant impacts on patient quality of life. Accurate diagnosis is therefore critical, utilising ACR/EULAR criteria that include both labial minor salivary gland (LMSG) biopsy and anti-SSA antibodies.
Methods: This retrospective study analysed medical records of 87 adults suspected of primary SS, who underwent both anti-SSA serology and LMSG biopsy.
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