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Exploring the Anticancer Potential of MonoHER (7-Mono-O-(β-Hydroxyethyl)-Rutoside): Mitochondrial-Dependent Apoptosis in HepG2 Cells.
Curr Issues Mol Biol
January 2025
The M-Lab, Department of Precision Medicine, GROW-Research Institute for Oncology and Reproduction, Maastricht University, 6200MD Maastricht, The Netherlands.
Background/aim: Flavonoids are a group of polyphenols, abundantly present in our diet. Although, based on their chemoprotective effects, intake of flavonoids is associated with a high anticancer potential as evidenced in in vitro and in vivo models, the molecular mechanism is still elusive. This study explores the antiproliferative and cytotoxic effects of the semi-synthetic flavonoid MonoHER (7-mono-O-(β-hydroxyethyl)-rutoside) in vitro on cancer cells.
View Article and Find Full Text PDFEnhanced ensemble learning-based uncertainty and sensitivity analysis of ventilation rate in a novel radiative cooling building.
Heliyon
January 2025
Department of Energy System Engineering, Faculty of Mechanical Engineering, K.N. Toosi University of Technology, No. 15, Pardis St., Molasadra Ave., Vanak Sq., Tehran, Iran.
The rising global demand for air conditioning systems, driven by increasing temperatures and urbanization, has led to higher energy consumption and greenhouse gas emissions. HVAC systems, particularly AC, account for nearly half of building energy use, highlighting the need for efficient cooling solutions. Passive cooling, especially radiative cooling, offers potential to reduce cooling loads and improve energy efficiency.
View Article and Find Full Text PDFBoat noise reduces vocalization rate and alters vocal characteristics in wild plainfin midshipman fish.
Mar Pollut Bull
January 2025
Department of Biology, University of Victoria, Victoria, BC V8P 5C2, Canada.
Anthropogenic noise pollution has been accelerating at an alarming rate, greatly altering aquatic soundscapes. Animals use various mechanisms to avoid acoustic masking in noisy environments, including altering calling rates or the frequency (pitch) of their vocalizations or increasing the amplitude (loudness) of their vocalizations (i.e.
View Article and Find Full Text PDFAssociations of Short-Term Ozone Exposure With Hypoxia and Arterial Stiffness.
J Am Coll Cardiol
January 2025
SKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, Center for Environment and Health, Peking University, Beijing, China; Research Station of Alpine Ecology Environment and Health at Tibet University, Lhasa, Tibet Autonomous Region, China. Electronic address:
Background: Epidemiological studies reported associations between ozone (O) exposure and cardiovascular diseases, yet the biological mechanisms remain underexplored. Hypoxia is a shared pathogenesis of O-associated diseases; therefore, we hypothesized that O exposure may induce changes in hypoxia-related markers, leading to adverse cardiovascular effects.
Objectives: This study aimed to investigate associations of short-term O exposure with hypoxic biomarkers and arterial stiffness.
Tensor Train Optimization for Conformational Sampling of Organic Molecules.
J Chem Theory Comput
January 2025
Institute of Physical Chemistry, RWTH Aachen University, Aachen 52074, Germany.
Exploring the conformational space of molecules remains a challenge of fundamental importance to quantum chemistry: identification of relevant conformers at ambient conditions enables predictive simulations of almost arbitrary properties. Here, we propose a novel approach, called TTConf, to enable conformational sampling of large organic molecules where the combinatorial explosion of possible conformers prevents the use of a brute-force systematic conformer search. We employ tensor trains as a highly efficient dimensionality reduction algorithm, effectively reducing the scaling from exponential to polynomial.
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