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Oral colon-retentive inulin gels protect against radiation-induced hematopoietic and gastrointestinal injury by improving gut homeostasis.
Int J Biol Macromol
December 2024
Beijing Institute of Radiation Medicine, Beijing 100850, China. Electronic address:
Ionizing radiation-induced injury often occurs in nuclear accidents or large-dose radiotherapy, leading to acute radiation syndromes characterized by hematopoietic and gastrointestinal injuries even to death. However, current radioprotective drugs are only used in hospitals with unavoidable side effects. Here, we heated the aqueous solution of inulin, a polysaccharide dietary fiber, forming colon-retentive gel as a radiation protector in radiotherapy.
View Article and Find Full Text PDFAlterations in Gut Microbiota Correlate With Hematological Injuries Induced by Radiation in Beagles.
Int J Microbiol
December 2024
State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Fengtai, Beijing 100071, China.
Dynamics of gut microbiota and their associations with the corresponding hematological injuries postradiation remain to be elucidated. Using single whole-body exposure to Co- ray radiation at the sublethal dose of 2.5 Gy, we developed a beagle model of acute radiation syndrome (ARS) and then monitored the longitudinal changes of gut microbiome and hematology for 45 days.
View Article and Find Full Text PDFHistological and Molecular Biological Changes in Canine Skin Following Acute Radiation Therapy-Induced Skin Injury.
Animals (Basel)
August 2024
College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea.
Radiation therapy is a crucial cancer treatment, but it can damage healthy tissues, leading to side effects like skin injuries and molecular alterations. This study aimed to elucidate histological and molecular changes in canine skin post-radiation therapy (post-RT) over nine weeks, focusing on inflammation, stem cell activity, angiogenesis, keratinocyte regeneration, and apoptosis. Four male beagles received a cumulative radiation dose of 48 Gy, followed by clinical observations, histological examinations, and an RT-qPCR analysis of skin biopsies.
View Article and Find Full Text PDFOptimizing Management of Cavernous Sinus Meningiomas: A Novel Strategy Integrating Endoscopic Endonasal and Transorbital Surgery with Adjuvant Stereotactic Radiotherapy.
World Neurosurg
November 2024
Division of Neurosurgery, Department of Surgery, Thammasat University Hospital, Faculty of Medicine, Thammasat University, Pathumthani, Thailand.
Background: Cavernous sinus meningiomas (CSMs) are challenging skull base tumors due to their proximity to vital neurovascular structures. Traditional aggressive transcranial resection often leads to significant morbidities with limited improvement of cranial nerve (CN) deficits. Recent advancements in endoscopic skull base surgery and stereotactic radiation therapy (SRT) offer a more conservative approach, facilitating tumor decompression while preserving critical structures.
View Article and Find Full Text PDFRevitalizing gut health: Liangxue guyuan yishen decoction promotes akkermansia muciniphila -induced intestinal stem cell recovery post-radiation in mice.
Phytomedicine
September 2024
Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, PR China; Medical College of Qinghai University, Xining, PR China; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, PR China; State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital, Beijing, PR China. Electronic address:
Article Synopsis
- Liangxue Guyuan Yishen Decoction (LGYD), a traditional Chinese medicine, has shown promising results in treating radiation-induced intestinal injury, but its mechanisms need further exploration for better understanding and potential pharmaceutical development.
- The study investigates how LGYD affects gut microbiota and short-chain fatty acids (SCFA) as part of its therapeutic effects on radiation-induced intestinal injury, utilizing various analytical methods to explore these relationships.
- Results indicate that LGYD enhances recovery from intestinal injury, boosts specific beneficial gut bacteria (like Akkermansia muciniphila), and increases SCFA levels, highlighting its potential as a treatment following high-dose radiation.
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