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Prognostic Role of Prolactin-Induced Protein (PIP) in Breast Cancer.
Cells
September 2023
Old Town Clinic, 50-127 Wroclaw, Poland.
Prolactin-inducible protein (PIP), also referred to as gross cystic disease fluid protein 15 (GCDFP-15), has been a trending topic in recent years due to its potential role as a specific marker in breast cancer. PIP binds to aquaporin-5 (AQP5), CD4, actin, fibrinogen, β-tubulin, serum albumin, hydroxyapatite, zinc α2-glycoprotein, and the Fc fragment of IgGs, and the expression of PIP has been demonstrated to be modulated by various cytokines, including IL4/13, IL1, and IL6. PIP gene expression has been extensively studied due to its captivating nature.
View Article and Find Full Text PDFThe Comprehensive Steroidome in Complete TSPO/PBR Knockout Mice under Basal Conditions.
Int J Mol Sci
January 2023
Disease and Hormones of the Nervous System, U1195 Inserm-Université Paris Saclay, 80 rue du Général Leclerc, 94276 Kremlin-Bicêtre, France.
The 18 kDa translocator protein (TSPO/PBR) is a multifunctional evolutionary highly conserved outer mitochondrial membrane protein. Decades of research has reported an obligatory role of TSPO/PBR in both mitochondrial cholesterol transport and, thus, steroid production. However, the strict dependency of steroidogenesis on TSPO/PBR has remained controversial.
View Article and Find Full Text PDFIs the glucocorticoid receptor a key player in prostate cancer?: A literature review.
Medicine (Baltimore)
July 2022
Department of Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, University of Texas, Houston, Texas, United States.
Glucocorticoids act through the glucocorticoid receptor (GR) and exert pleiotropic effects in different cancer types. In prostate cancer cells, GR and androgen receptor (AR) share overlapping transcriptomes and cistromes. Under enzalutamide treatment, GR signaling can bypass AR activation and promote castration resistance via the expression of a subset of AR-target genes.
View Article and Find Full Text PDFPsychological Stress in Patients with Atopic Dermatitis.
Acta Dermatovenerol Croat
December 2018
Prof. Liborija Lugović-Mihić, MD, PhD, Department of Dermatovenereology Sestre milosrdnice University Hospital Center, Vinogradska c. 29, 10000 Zagreb, Croatia;
Atopic dermatitis (AD) is a frequent dermatosis with a growing incidence and multifactorial and complex pathogenic mechanisms that are still being investigated. Although the connection between AD and psychological stress has been known for a long time, there is a lack of reliable and objective indicators for the characterization of this association. Psychological stress triggers complex immune pathways.
View Article and Find Full Text PDFSeasonal changes in plasma testosterone and cortisol suggest an androgen mediated regulation of the pituitary adrenal axis in the Tarabul's gerbil Gerbillus tarabuli (Thomas, 1902).
Gen Comp Endocrinol
March 2018
Université des Sciences et de la Technologie Houari Boumediene (USTHB), Laboratoire de recherche sur les zones arides (LRZA), Faculté des Sciences Biologiques, BP 32, El-Alia, 16111 ou BP 44, Alger Gare, 16000, DZ, Algeria. Electronic address:
In the desert gerbil Gerbillus tarabuli (Thomas, 1902), cortisol is the main glucocorticosteroid produced by the adrenal glands. Plasma cortisol concentrations show highest values when testosterone is reduced and lowest values during the breeding season which occurs from early winter to late spring. In order to specify the implication of testicular androgens in these corticosteroid seasonal variations we investigated the effects induced by gonadectomy performed during the breeding season on the pituitary adrenal axis.
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