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Grapefruit-derived nootkatone potentiates GABAergic signaling and acts as a dual-action mosquito repellent and insecticide.
Curr Biol
November 2024
Department of Biology, Lund University, Lund 22362, Sweden; Max Planck Center next Generation Chemical Ecology, Lund 22362, Sweden. Electronic address:
Humanity has long battled mosquitoes and the diseases they transmit-a struggle intensified by climate change and globalization, which have expanded mosquito ranges and the spread of associated diseases. Additionally, widespread insecticide resistance has reduced the efficacy of current control methods, necessitating new solutions. Nootkatone, a natural compound found in grapefruit, shows promise as both a mosquito repellent and an insecticide.
View Article and Find Full Text PDFAngiopoietin-like protein 8 directs DNA damage responses towards apoptosis by stabilizing PARP1-DNA condensates.
Cell Death Differ
November 2024
School of Pharmacy, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, 430030, China.
Article Synopsis
- Cells react to DNA damage through responses like DNA repair or programmed cell death (apoptosis), but the factors influencing these choices are not well understood.
- The protein ANGPTL8, which is usually involved in lipid metabolism, also plays a key role in guiding cells towards apoptosis instead of repair when faced with DNA damage.
- ANGPTL8 interacts with a protein called PARP1, promoting apoptosis by enhancing PARP1's accumulation on damaged DNA, while its own levels decrease after DNA damage to prevent excessive toxicity.
Association of Drugs for Sale on the Internet and Official Health Indicators: Darknet Parsing and Correlational Study.
JMIR Form Res
November 2024
National Research University Higher School of Economics, Moscow, Russian Federation.
Background: Studying illicit drug circulation and its effects on population health is complicated due to the criminalization of trade and consumption. Illicit drug markets have evolved with IT, moving digital to the "darknet." Previous research has analyzed darknet market listings and customer reviews.
View Article and Find Full Text PDFGlioblastoma therapy: State of the field and future prospects.
Life Sci
December 2024
Field Neurosciences Institute Laboratory for Restorative Neurology, Central Michigan University, Mount Pleasant, MI, USA; Program in Neuroscience, Central Michigan University, Mount Pleasant, MI, USA; College of Medicine, Central Michigan University, Mount Pleasant, MI, USA. Electronic address:
Glioblastoma (GB) is a cancerous brain tumor that originates from glial cells and leads to thousands of deaths each year and a five-year survival of only 6.8 %. Treatments for GB include surgery, chemotherapy, radiation, and immunotherapy.
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