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Shifting paradigms in primary aldosteronism: reconsideration of screening strategy via integrating pathophysiological insights.
Front Endocrinol (Lausanne)
January 2025
Endocrinology and Diabetes Center, Yokohama Rosai Hospital, Yokohama, Japan.
Several decades have passed since the description of the first patient with primary aldosteronism (PA). PA was initially classified in two main forms: aldosterone-producing adenoma (APA) and idiopathic hyperaldosteronism (IHA). However, the pathogenesis of PA has now been shown to be far more complex.
View Article and Find Full Text PDFImmunometabolic alterations in type 2 diabetes mellitus revealed by single-cell RNA sequencing: insights into subtypes and therapeutic targets.
Front Immunol
January 2025
Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, China.
Background: Type 2 Diabetes Mellitus (T2DM) represents a major global health challenge, marked by chronic hyperglycemia, insulin resistance, and immune system dysfunction. Immune cells, including T cells and monocytes, play a pivotal role in driving systemic inflammation in T2DM; however, the underlying single-cell mechanisms remain inadequately defined.
Methods: Single-cell RNA sequencing of peripheral blood mononuclear cells (PBMCs) from 37 patients with T2DM and 11 healthy controls (HC) was conducted.
Descriptive Analysis of Preoperative Breast Reconstruction Patient Expectations Using the BREAST-Q Expectations Module.
Plast Surg (Oakv)
February 2025
Division of Plastic and Reconstructive Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Patient expectations have been shown to influence postoperative outcomes across surgical specialties. However, the impact of expectations in breast reconstruction is not well understood. The purpose of this project is to perform the first large-scale analysis and classification of BREAST-Q Expectations responses in patients undergoing implant-based reconstruction.
View Article and Find Full Text PDFChildhood BMI trajectories and sociodemographic factors in an Italian pediatric population.
Sci Rep
January 2025
Unit of Biostatistics, Epidemiology and Public Health, Department of Cardio-Thoraco- Vascular Sciences and Public Health, University of Padua, Padua, Italy.
Childhood obesity is a growing global concern due to its long-term health consequences. Yet, more research relying on multiple time-point BMI measurements is warranted to gain further insight into obesity's temporal trends. We aimed to identify BMI trajectories in children aged 2-10 years and evaluate their association with sociodemographic factors.
View Article and Find Full Text PDFIdentification of diabetic retinopathy lesions in fundus images by integrating CNN and vision mamba models.
PLoS One
January 2025
Department of Radiology, Yantaishan Hospital, Yantai, Shandong, China.
Diabetic retinopathy, a retinal disorder resulting from diabetes mellitus, is a prominent cause of visual degradation and loss among the global population. Therefore, the identification and classification of diabetic retinopathy are of utmost importance in the clinical diagnosis and therapy. Currently, these duties are extensively carried out by manual examination utilizing the human visual system.
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