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Bioleaching of lanthanum from nickel metal hydride dry battery using siderophores produced by Pseudomonas sp.
World J Microbiol Biotechnol
January 2025
Botany Department, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt.
There is still much to be learned about the properties of siderophores and their applications. This study was designed to characterize and optimize the production of the siderophore produced by a marine bacterium Pseudomonas sp. strain ASA235 and then evaluate their use in bioleaching of rare earth elements (REEs) from spent Nickel-metal hydride (NiMH) batteries.
View Article and Find Full Text PDFEnhancing Microemulsion-Based Therapeutic Drug Delivery: Exploring Surfactants, Co-Surfactants, and Quality-by-Design Strategies within Pseudoternary Phase Diagrams.
Crit Rev Ther Drug Carrier Syst
January 2025
Associate Professor of Pharmaceutics, Faculty of Health and Allied Sciences, Amity University Noida India, Pharmaceutics Domain, Uttar Pradesh, India; Member, Indian National Young Academy of Sciences (INYAS), INSA, New Delhi, India.
Microemulsions (MEs) are homogeneous, isotropic, transparent, and thermodynamically stable mixtures of water, oil, and surfactants. Their unique properties have garnered increasing interest across various fields, including chemistry, pharmacology, biotechnology, and biology. This review aims to provide a comprehensive overview of ME compositions, their macroscopic appearances, and the roles of their essential components - oil, water, surfactant, and co-surfactant - in controlling the nature and stability of MEs.
View Article and Find Full Text PDFPressure Protein Denaturation Compared to Thermal and Chemical Unfolding: Analyses with Cooperative Models.
J Phys Chem B
January 2025
Biozentrum, University of Basel, Spitalstrasse 41, CH-4056 Basel, Switzerland.
The thermodynamics of pressure-induced protein denaturation could so far not be directly compared with protein denaturation induced by temperature or chemical agents. Here, we provide a new cooperative model for pressure-induced protein denaturation that allows the quantitative comparison of all three denaturing processes based on their free energy, enthalpy, entropy, and cooperativity. As model proteins, we use apolipoprotein A-1 and lysozyme.
View Article and Find Full Text PDFNonbonded Molecular Interaction Controls Aggregation Kinetics of Hydrophobic Molecules in Water.
Langmuir
January 2025
Department of Chemical Engineering, Indian Institute of Technology, Jodhpur 342037, India.
Molecular aggregation frequently occurs during material synthesis, cellular processes, and drug delivery systems, often resulting in decreased performance and efficiency. One major reason for such aggregation in an aqueous solution is hydrophobicity. While the basic understanding of the aggregation process of hydrophobic molecules from a thermodynamic standpoint is known, the present literature lacks a connection between the aggregation kinetics and the molecular basis of hydrophobicity.
View Article and Find Full Text PDFJAK3 Inhibitors: Covalent and Noncovalent Interactions of a Cyanamide Group Investigated by Multiscale Free-Energy Simulations.
J Chem Inf Model
January 2025
Medicinal Chemistry and Drug Design Technologies Department, Chiesi Farmaceutici S.p.A., Largo F. Belloli 11/A, 43122 Parma, Italy.
Janus kinase type 3 (JAK3), an emerging target for treating autoimmune diseases, possesses a front pocket cysteine that is targeted by covalent modifiers, best represented by the marketed drug ritlecitinib (). Recently, 2,3-dihydro-1-inden-1-ylcyanamides have been developed as novel JAK3 inhibitors. Among them, the -(6-(7-pyrrolo[2,3-]pyrimidin-4-yl)-2,3-dihydro-1-inden-1-yl)cyanamide inhibitor () and its methylated analogue (), while being potent inhibitors, displayed different mechanisms of action (covalent vs noncovalent) and binding modes (Casimiro-Garcia et al.
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