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Therapeutical potential of natural products in treatment of pancreatic cancer: a review.
Mol Biol Rep
January 2025
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India.
Pancreatic cancer remains as global health challenge, ranking as the seventh leading cause of cancer-related deaths worldwide with high mortality rates and a low five-year survival rate. Despite advancements in conventional therapies, including surgery, chemotherapy, and radiation, the overall survival rates for pancreatic cancer patients have shown minimal improvement. Consequently, there is an urgent need for alternative therapeutic strategies.
View Article and Find Full Text PDFAssessment of the Properties and Mechanism of Three Lotus (Nelumbo nucifera Gaertn.) Parts for Sleep Improvement.
Chem Biodivers
January 2025
Shanghai General Hospital, department of clinical Pharmacy, 85 Wujin Road, Hongkou District, Shanghai, 200080, Shanghai, CHINA.
Lotus leaves (LL), petals (LP), and seeds (LS) are believed to have properties that can improve sleep. However, their efficacy in improving sleep has not been fully validated. This study aimed to investigate the multitarget mechanisms of extracts from these lotus parts for sleep improvement using chemical analysis, bioactivity assessment, meta-analysis, network pharmacology evaluation, and molecular docking.
View Article and Find Full Text PDFIn Vivo Investigation of the Effects of Nonylphenol on the Pituitary-Adrenal Axis and Pineal Gland in Male Rats.
Basic Clin Pharmacol Toxicol
March 2025
Department of Biology, Faculty of Science, Hacettepe University, Ankara, Turkey.
The pineal gland secretes melatonin, which regulates various physiological processes; damage to this gland disrupts these functions. This study aimed to investigate the effect of nonylphenol on the pineal gland and the pituitary-adrenal axis, which is associated with this system. The study was initiated using Wistar albino male rats on their postnatal 21st day, a critical developmental stage for endocrine regulation.
View Article and Find Full Text PDFTwo new phenolic constituents from the Busch roots.
Nat Prod Res
January 2025
Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province, Qinghai MinZu University, Xining, China.
Two new phenolic compounds aconitol A () and B (), together with three known compounds including one phenolic constituent () and two diterpenoid alkaloids (-), were isolated from the roots of . Their structures were assigned by HRESIMS, extensive spectral methods and compared with literature data. All obtained compounds (-) were tested for their inhibitory activity against NO production in LPS-activated RAW 264.
View Article and Find Full Text PDF[Use of secondary raw materials of the wine industry for the production of a functional fermented milk product].
Vopr Pitan
January 2025
M.G. Safronov Yakut Scientific Research Institute of A griculture - Division of Federal Research Centre "The Yakut Scientific Centre of the Siberian Branch of the Russian Academy of Sciences", 677001, Yakutsk, The Republic of Sakha (Yakutia), Russian Federation.
The development of new technologies and the production of functional food based on secondary raw materials is an urgent problem that requires careful study. of the research was to study the chemical composition of the powder from the pomace of Riesling and Cabernet Sauvignon grape varieties, as well as the possibility of using this powder for the preparation of functional yogurt. .
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