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Conservative management of emphysematous esophagitis-a case report.
Mediastinum
July 2024
Department of Radiology, Inje University Sanggye Paik Hospital, Seoul, Korea.
Background: Emphysematous esophagitis is a very rare disease and there are only a few previous reports in the literature. Previously reported cases have resulted in emphysematous esophagitis following anterior cervical procedures or ingestion of hydrogen peroxide (HP). In this report, we describe a case in which a patient with emphysematous esophagitis accompanied by gastritis without the above predisposing factors was treated with conservative treatment.
View Article and Find Full Text PDFIntratumoral Bacteria are Uncommon in Gastrointestinal Stromal Tumor.
Ann Surg Oncol
November 2024
Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Article Synopsis
- Gastrointestinal stromal tumors (GISTs) are the most prevalent type of sarcoma in humans, predominantly occurring in the stomach or small intestine, with over 5000 new cases diagnosed annually in the USA.
- A study investigated the presence of bacteria within GISTs by analyzing 25 tumor samples from 24 patients using advanced genetic sequencing techniques.
- Results showed that most samples had negligible bacterial presence, while two samples indicated normal intestinal bacteria, but only in tumors where the mucosal lining was disrupted.
[A Case of Necrosis of the Gastric Remnant Following Laparoscopic Distal Gastrectomy].
Gan To Kagaku Ryoho
October 2024
Dept. of Digestive Surgery, Fujisawa City Hospital.
An 80-year-old man underwent laparoscopic distal gastrectomy, D2 lymphadenectomy, and Billroth Ⅰ reconstruction for gastric cancer. The short gastric artery and vein were completely preserved. The patient developed a fever on the second postoperative day, and a blood test on the third day showed high inflammation findings, and contrast-enhanced CT scan revealed decreased gastric wall blood flow of the anal side of the remnant stomach.
View Article and Find Full Text PDFPersistence of activated anti-mesothelin hYP218 chimeric antigen receptor T cells in the tumour is associated with efficacy in gastric and colorectal carcinomas.
Clin Transl Med
November 2024
Thoracic and GI Malignancies Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Patients with advanced gastric and colorectal cancers have limited treatment options. Since mesothelin is highly expressed in these tumour types, we evaluated the therapeutic benefits of anti-mesothelin hYP218 CAR T cells alone, and in combination with anti-PD1 antibody, pembrolizumab. GEPIA analysis was performed using human gastric (n = 408) and colon cancer tumours (n = 275) in TCGA database, to evaluate mRNA expression of mesothelin, compared to normal tissues.
View Article and Find Full Text PDFLessons learned from 150 total gastrectomies for prevention of cancer.
J Gastrointest Surg
January 2025
Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States. Electronic address:
Background: Prophylactic total gastrectomy (PTG) is performed in carriers of CDH1 pathogenic and likely pathogenic (P/LP) variants and is becoming more frequent with broader use of germline genetic testing. There is an unmet need to standardize care and enhance outcomes among patients undergoing surgery for the prevention of gastric cancer.
Methods: This was a retrospective analysis of 150 individuals with germline CDH1 P/LP variants who underwent PTG as part of a prospective natural history study from October 2017 to May 2023.
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