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Müllerian-type carcinosarcoma arising in gastric endometriosis: Case report and review of the literature.
Clin Case Rep
March 2024
Department of General Surgery, Section of Surgical Oncology Univeristy of Chicago Chicago Illinois USA.
Although endometriosis is a common condition, both extrapelvic endometriosis and endometriosis associated malignancy (EAM) are rare. We describe the first reported case of a patient with Müllerian-type carcinosarcoma arising in gastric endometriosis.
View Article and Find Full Text PDFThe protein kinase TAOK3, belongs to the MAP kinase family, is one of three closely related members, namely TAOK1, TAOK2, and TAOK3. We performed a pan-cancer investigation of TAOK3 across different cancer types, including uterine carcinosarcoma, adenocarcinoma of the stomach and pancreas, and endometrial carcinoma of the uterus, to better understand TAOK3's role in cancer. In at least 16 types of cancer, our findings indicate that TAOK3 expression levels differ considerably between normal and tumor tissues.
View Article and Find Full Text PDFComprehensive analysis and immunohistochemistry localization of NRP1 expression in pancancer and normal individual tissues in relation to SARS‑CoV‑2 susceptibility.
Exp Ther Med
February 2024
Key Laboratory of Epigenetics and Oncology, The Research Center for Preclinical Medicine, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.
Neuropilin 1 (NRP1/CD304) is a typical membrane-bound co-receptor for vascular endothelial growth factor, semaphorin family members and viral severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, NRP1 expression levels across cancer types and the potential role of SARS-CoV-2 infection in patients with cancer are not clear. Online databases, such as The Cancer Genome Atlas database of Human Protein Atlas, Gene Expression Profiling Interactive Analysis and cBioPortal were used for the expression analysis in this study.
View Article and Find Full Text PDFAPOBEC3C is a novel target for the immune treatment of lower-grade gliomas.
Neurol Res
March 2024
Department of Neurosurgery, The affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou, Jiangsu, China.
Article Synopsis
- APOBEC type 3C (A3C) is identified as a potential cancer biomarker for lower-grade gliomas (LGGs), but its specific role in improving clinical outcomes through immunotherapy is still unclear.
- Research utilized RNA sequencing and bioinformatic analyses to find that A3C is expressed significantly higher in LGGs compared to normal tissues, making it an independent predictor for patient prognosis.
- The study also discovered that A3C is associated with immune cell infiltration and chemotherapy sensitivity, suggesting that targeting A3C could improve immunotherapy effectiveness for LGGs.
Asymptomatic giant gastric carcinosarcoma.
BMJ Case Rep
October 2023
Department of Surgical Gastroenterology, Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India.
Carcinosarcoma is an aggressive malignant neoplasm separate from adenocarcinoma with need for a radical early treatment for good response and survival. Less than 75 cases have been reported worldwide. Here, we report a case of an asymptomatic carcinosarcoma of stomach in a lady in her 70's presenting incidentally who underwent distal gastrectomy with Billroth II reconstruction for a large epigastric mass along with a review of literature.
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