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Safety evaluation of targeted osmotic lysis therapy in Beagles.
Am J Vet Res
December 2024
Phantom Laboratory, Greenwich, NY.
Objective: The objective of this study was to satisfy the US FDA's Center for Devices and Radiological Health regarding the safety of targeted osmotic lysis (TOL), a novel treatment for advanced carcinomas, in Beagle dogs.
Methods: 12 intact Beagle dogs, 6 males and 6 females, were divided into 2 treatment groups of 6, each receiving 3 TOL cycles. For each 6-day cycle, digoxin was administered orally at 0.
How NINJ1 mediates plasma membrane rupture and why NINJ2 cannot.
Cell
December 2024
Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106, USA. Electronic address:
Ninjurin-1 (NINJ1) is an active executioner of plasma membrane rupture (PMR), a process previously thought to be a passive osmotic lysis event in lytic cell death. Ninjurin-2 (NINJ2) is a close paralog of NINJ1 but cannot mediate PMR. Using cryogenic electron microscopy (cryo-EM), we show that NINJ1 and NINJ2 both assemble into linear filaments that are hydrophobic on one side but hydrophilic on the other.
View Article and Find Full Text PDFDevelopment and Biological Characterization of Cancer Biomimetic Membrane Nanovesicles for Enhancing Therapy Efficacy in Human Glioblastoma Cells.
Nanomaterials (Basel)
November 2024
Department of Biology and Biotechnology, University of Pavia, 27100 Pavia, Italy.
As nanocarriers of a new generation, biomimetic nanovesicles are an emerging class of therapeutic tools whose surface is integrated or fabricated with biomaterials capable of mimicking the biological features and functions of native cells. Thanks to this, biomimetic nanovesicles, in particular, those made by plasma membrane moieties, possess greatly improved biocompatibility, high target specificity, a long retention time, and minimal undesired immune responses. For these reasons, a multitude of progenitor cells including cancer ones were employed as templates to generate biomimetic or membrane-camouflaged nanovesicles hosting different therapeutic compounds.
View Article and Find Full Text PDFInvolvement of aquaporins in Shiga toxin-induced swelling and water transport dysfunction in human renal microvascular endothelial cells.
Biochim Biophys Acta Mol Cell Res
January 2025
Universidad de Buenos Aires, Facultad de Ciencias Médicas, Departamento de Ciencias Fisiológicas, Laboratorio de Fisiopatogenia, Buenos Aires C1121ABG, Argentina; CONICET - Universidad de Buenos Aires, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO Houssay), Buenos Aires C1121ABG, Argentina. Electronic address:
One of the hallmarks of Shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome (STEC-HUS) is kidney damage. Our previous research demonstrated that Shiga toxin type 2 (Stx2a) decreases cell viability and induces swelling of human glomerular endothelial cells (HGEC). However, Stx2a can disrupt net water transport across HGEC monolayers without affecting cell viability.
View Article and Find Full Text PDFPeptidoglycan-tethered and free forms of the Braun lipoprotein are in dynamic equilibrium in .
Elife
October 2024
Centre de Recherche des Cordeliers, Sorbonne Université, INSERM, Université de Paris, Paris, France.
Article Synopsis
- Peptidoglycan (PG) is a strong net-like structure that surrounds bacteria, keeping them safe from bursting in watery environments.
- Scientists created a special method using heavy isotopes and mass spectrometry to learn how new parts are added to this PG structure during bacterial growth.
- Their findings reveal that the protein Braun lipoprotein (Lpp) is added to PG and that it moves around a lot, sometimes being attached and other times being free within the bacterial wall.
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