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Conditional Pten inactivation in pituitary results in sex-specific prolactinoma formation.
Biochim Biophys Acta Mol Basis Dis
January 2025
Unidad de Gestión de Endocrinología y Nutrición, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Spain. Electronic address:
Pituitary tumors, including prolactinomas, present significant clinical challenges that require a deeper understanding of their molecular roots for improved diagnostics and therapies. Here, we investigate the role of the phosphatase and tensin homolog (PTEN)/phosphoinositide 3-kinase (PI3K) pathway in pituitary tumorigenesis using a mouse model. Conditional knockout of Pten in all pituitary cell lineages resulted in prolactinoma formation exclusively in female mice, demonstrating the critical role of PTEN in pituitary homeostasis.
View Article and Find Full Text PDFAdvancement in perioperative management of pituitary adenomas-Current concepts and best practices.
J Neuroendocrinol
November 2024
Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York, USA.
Pituitary adenomas are very common representing 18.1% of all brain tumors and are the second most common brain pathology. Transsphenoidal surgery is the mainstay of treatment for all pituitary adenomas except for prolactinomas which are primarily treated medically with dopamine agonists.
View Article and Find Full Text PDFReconsideration of Surgical Indication for Prolactin-producing Pituitary Tumor Focusing on Visual Impairment.
Neurol Med Chir (Tokyo)
April 2024
Department of Neurosurgery, Tokyo Women's Medical University.
Prolactin-producing pituitary tumor (PRLoma) is the most prevalent functional pituitary tumor. If the tumor becomes large, vision can be impaired. In contrast to other pituitary tumors, cabergoline (CAB) is extremely effective for PRLoma and has become the first-line treatment.
View Article and Find Full Text PDFExecutive summary of the expert consensus document from the Spanish Society of Neurosurgery and the Spanish Society of Endocrinology and Nutrition: Clinical recommendations on the perioperative management of pituitary tumors.
Endocrinol Diabetes Nutr (Engl Ed)
November 2023
Servicio de Endocrinología y Nutrición, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, A Coruña, Spain. Electronic address:
Pituitary tumors (PT) account for 15% of intracranial tumors affect 10.7%-14.4% of the population although the incidence of clinically relevant PT is 5.
View Article and Find Full Text PDFExecutive summary of the expert consensus document from the Spanish Society of Neurosurgery and the Spanish Society of Endocrinology and Nutrition: clinical recommendations on the perioperative management of pituitary tumors.
Neurocirugia (Astur : Engl Ed)
November 2023
Servicio de Endocrinología y Nutrición, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, A Coruña, Spain. Electronic address:
Pituitary tumors (PT) account for 15% of intracranial tumors affect 10.7-14.4% of the population although the incidence of clinically relevant PT is 5.
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