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CalciumZero: a toolbox for fluorescence calcium imaging on iPSC derived brain organoids.
Brain Inform
January 2025
Department of Psychiatry, Columbia University, 1051 Riverside Drive, New York, NY, 10032, USA.
Calcium plays an important role in regulating various neuronal activities in human brains. Investigating the dynamics of the calcium level in neurons is essential not just for understanding the pathophysiology of neuropsychiatric disorders but also as a quantitative gauge to evaluate the influence of drugs on neuron activities. Accessing human brain tissue to study neuron activities has historically been challenging due to ethical concerns.
View Article and Find Full Text PDFAssessment of Speech Processing and Listening Effort Associated With Speech-on-Speech Masking Using the Visual World Paradigm and Pupillometry.
Trends Hear
January 2025
Faculty of Medicine and University Hospital Cologne, Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany.
Speech-on-speech masking is a common and challenging situation in everyday verbal communication. The ability to segregate competing auditory streams is a necessary requirement for focusing attention on the target speech. The Visual World Paradigm (VWP) provides insight into speech processing by capturing gaze fixations on visually presented icons that reflect the speech signal.
View Article and Find Full Text PDFAcute cannabidiol administration reduces alcohol craving and cue-induced nucleus accumbens activation in individuals with alcohol use disorder: the double-blind randomized controlled ICONIC trial.
Mol Psychiatry
December 2024
Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim/ University of Heidelberg, Heidelberg, Germany.
Although alcohol use disorder (AUD) is highly prevalent, only a few medications are approved for its treatment leaving much room for improvement. Cannabidiol (CBD) might be a particularly promising candidate, with preclinical data suggesting that CBD is effective in targeting AUD symptoms and disease processes that drive alcohol use and relapse, due to its anti-craving, stress-reducing, and anti-compulsive effects. Here we report data from the double-blind randomized controlled ICONIC trial that compared the effects of a single dose of 800 mg cannabidiol against placebo (PLC) in N = 28 individuals with AUD.
View Article and Find Full Text PDFChromosomal-level reference genome assembly of muskox (Ovibos moschatus) from Banks Island in the Canadian Arctic, a resource for conservation genomics.
Sci Rep
September 2024
The Centre for Applied Genomics, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 686 Bay Street, Rm 13.9713, Suite 03-6577, Toronto, ON, M5G 0A4, Canada.
The muskox (Ovibos moschatus), an integral component and iconic symbol of arctic biocultural diversity, is under threat by rapid environmental disruptions from climate change. We report a chromosomal-level haploid genome assembly of a muskox from Banks Island in the Canadian Arctic Archipelago. The assembly has a contig N50 of 44.
View Article and Find Full Text PDFLess is Better than More: Anthropomorphic App Icons With Small versus Large Tilt Angles Were Perceived as More Vivid.
Percept Mot Skills
October 2024
Center for Cognition and Brain Disorders, the Affiliated Hospital of Hangzhou Normal University, Hangzhou, P. R. China.
Article Synopsis
- The study investigated how tilting anthropomorphic app icons affects users' perceptions of their vividness through three experiments.
- In Experiment 1, a 45° left tilt made icons seem more vivid.
- Experiment 2 found that small tilts (like 30°) increased perceptions of dynamism and vividness, while Experiment 3 confirmed that slight tilting is a successful design strategy to enhance icon appeal.
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