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Zebrafish as a Visible Neuroinflammation Model for Evaluating the Anti-Inflammation Effect of Curcumin-Loaded Ferritin Nanoparticles.
ACS Appl Mater Interfaces
January 2025
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau 999078, China.
It is crucial to inhibit the neuroinflammation response as it is a prominent factor contributing to the pathogenesis of neurodegenerative disorders. However, the limited development of neuroinflammation models dramatically hinders the efficiency of nanomedicine discovery. In recent years, the optically transparent zebrafish model provided unique advantages for imaging of the whole body, allowing the progression of the disease to be visualized.
View Article and Find Full Text PDFFour Alkaloids from with Antitumor Activity via Disturbing Glutathione Homeostasis.
J Org Chem
January 2025
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, P. R. China.
Alstoschoquinolines A-D (-) representing three unprecedented scaffolds were isolated from the leaves of through direct separation by LC/MS detection. and consisted of a 5/6/5-coupled quinoline architecture containing six consecutive chiral carbons, while and possessed a bridged ring featuring 6/6/6/6 and 6/6/8/6 skeletons, respectively. They might be derived from the corynantheine-type indole alkaloid via sequential oxidation and rearrangement.
View Article and Find Full Text PDFNeuroactive steroid exposure impacts neurodevelopment: Comparison of human and rodent placental contribution.
J Neuroendocrinol
January 2025
Department of Pediatrics, Columbia University Irving Medical Center, New York, New York, USA.
The placenta is a fetal endocrine organ that secretes many neuroactive factors, including steroids, that play critical roles in brain development. The study of the placenta-brain axis and the links between placental function and brain development represents an emerging research area dubbed "neuroplacentology." The placenta drives many circulating fetal steroids to very high levels during gestation.
View Article and Find Full Text PDFDNA Aptamer-Polymer Conjugates for Selective Targeting of Integrin α4β1 T-Lineage Cancers.
ACS Appl Mater Interfaces
January 2025
Department of Bioengineering, University of Washington, Seattle, Washington 98195, United States.
Selective therapeutic targeting of T-cell malignancies is difficult due to the shared lineage between healthy and malignant T cells. Current front-line chemotherapy for these cancers is largely nonspecific, resulting in frequent cases of relapsed/refractory disease. The development of targeting approaches for effectively treating T-cell leukemia and lymphoma thus remains a critical goal for the oncology field.
View Article and Find Full Text PDFOverfeeding and overweight rapidly reprogram inflammatory signaling.
Clin Immunol
January 2025
Division of Immunology, Boston Children's Hospital, Boston, MA, United States of America. Electronic address:
Epidemiologic studies have shown a continuous increase in mortality risk associated with overweight, thus highlighting the health risks beginning before the onset of obesity. However, early changes in inflammatory signaling induced by an obesogenic diet remain largely unknown since studies of obesity typically utilize models induced by months of continuous exposure to a high-fat diet. Here, we investigated how short-term overfeeding remodels inflammatory signaling.
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