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Identification and characterization of spontaneous AA amyloidosis in CD-1 mice used in toxicity studies: implications of SAA1 and SAA2 copy number variations.
J Toxicol Pathol
January 2025
Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara-shi, Kanagawa 252-5201, Japan.
Amyloidosis is characterized by the extracellular deposition of insoluble protein fibrils that cause cellular damage and dysfunction in organs and tissues. Multiple types of amyloidosis and their causative precursor proteins have been identified in humans and animals. In toxicological studies, a high incidence of spontaneous amyloidosis has been reported in CD-1 mice; however, the precursor protein responsible remains unclear.
View Article and Find Full Text PDFInvestigation into Drug-Induced Liver Damage Using Multimodal Mass Spectrometry Imaging.
J Am Soc Mass Spectrom
January 2025
Maastricht MultiModal Molecular Imaging Institute (M4i), Division of Imaging Mass Spectrometry, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands.
Drug toxicity during the development of candidate pharmaceuticals is the leading cause of discontinuation in preclinical drug discovery and development. Traditionally, the cause of the toxicity is often determined by histological examination, clinical pathology, and the detection of drugs and/or metabolites by liquid chromatography-mass spectrometry (LC-MS). While these techniques individually provide information on the pathological effects of the drug and the detection of metabolites, they cannot provide specific molecular spatial information without additional experiments.
View Article and Find Full Text PDFMetal contamination in the Ashtamudi Wetland ecosystem: Source identification, toxicological risk assessment of Ni, Cd, Cr, and Pb and remediation strategies.
Mar Pollut Bull
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Department of Chemical Oceanography, Cochin University of Science and Technology, Cochin 682016, India. Electronic address:
This study examines the presence of potentially toxic elements (PTEs) in the surface sediments and water of the Ashtamudi wetland, a Ramsar site on India's southwest coast. The average concentration of PTEs in water(μg/L) and in sediments (mg/kg) follows the order Fe(147.89) > Zn(107.
View Article and Find Full Text PDFBioorthogonal Synthesis of Biomimetic Nanoparticles for Screening Chemical Hazards in Food Samples.
Anal Chem
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School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.
The ability to identify unknown risks is the key to improving the level of food safety. However, the conventional nontargeted screening methods for new contaminant identification and risk assessment remain difficult work. Herein, a toxic-oriented screening platform based on high-expression epidermal growth factor receptor HEK293 cell membrane-coated magnetic nanoparticles (EGFR/MNPs) was first used for the discovery of unknown contaminants from food samples.
View Article and Find Full Text PDFCell viability assessment by using GelRed/SYTO 9-based double staining.
Methods Appl Fluoresc
January 2025
Key Laboratory of Longevity and Aging-related Diseases of Chinese Ministry of Education, Guangxi Colleges and Universities Key Laboratory of Biological Molecular Medicine Research, School of Basic Medical Sciences, Guangxi Medical University, Nanning, Guangxi 530021, People's Republic of China.
Cell viability assessment plays a crucial role in biological research, pharmaceutical development, and toxicological identification. Here, we used GelRed, a sensitive and safer nucleic acid dye, to selectively label dead cells with red fluorescence (FL) thus distinguishing dead cells from live ones. Further more, the combined use of GelRed and SYTO 9 (another nucleic acid dye) enabled the clear differentiation in FL spectra between the two physiological statuses.
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