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Background: Intrahepatic cholangiocarcinoma (ICC) presents a significant clinical challenge due to its high fatality rate and limited surgical candidacy. With only 30-40% of patients eligible for surgery upon diagnosis, alternative therapies are imperative. This study assesses the efficacy of Yttrium-90 (Y-90) radioembolization for unresectable ICC patients in a non-university tertiary care center (NUTCC).
View Article and Find Full Text PDFEffects of UV-B light exposure during automatic milking on vitamin D levels in Holstein Friesian cows.
Front Vet Sci
January 2025
Clinic for Reproduction and Large Animals-Section for Ruminants, Veterinary Faculty, University of Ljubljana, Ljubljana, Slovenia.
Vitamin D is essential for cattle and can be synthesized in the skin under ultraviolet irradiation. This study investigated the effects of narrow-band UV-B irradiation during automatic milking on blood vitamin D concentration and the influence of hair and black skin areas on cutaneous vitamin D synthesis in Holstein Friesian cows. Fifty-one cows were stratified by milk yield, days after calving, and percentage of black skin, then divided into three groups: shaved and irradiated (80 J/m), unshaved and irradiated (129-305 J/m), and a control group.
View Article and Find Full Text PDFEstimation of dose to a bystander from F-18 FDG patients using Monte Carlo simulation in clinical exposure scenarios.
Phys Eng Sci Med
January 2025
Department of Physics and Radiation Safety, Nepean Hospital, Penrith, New South Wales, Australia.
The radiation exposure to bystanders from nuclear medicine patients is a common concern raised in nuclear medicine departments. The GATE (Geant4 Application for Tomographic Emission) Monte Carlo radiation transport application was used to estimate the dose to a bystander. Two voxelised phantoms were utilised in a GATE Monte Carlo simulation as the radiation source and target.
View Article and Find Full Text PDFAssessment of Hsp90β-selective inhibitor safety and on-target effects.
Sci Rep
January 2025
Department of Chemistry and Biochemistry, The University of Notre Dame, 305 McCourtney Hall, Notre Dame, IN, 46556, USA.
The heat shock protein 90 (Hsp90) family of molecular chaperones mediates the folding and activation of ~ 400 client proteins, many of which contribute to oncogenesis. As a result, Hsp90 pan-inhibitors, which inhibit all four Hsp90 isoforms, have been investigated in the clinic for the treatment of cancer. Unfortunately, detrimental side effects were observed and hindered the clinical development of pan-Hsp90 inhibitors.
View Article and Find Full Text PDF1-year efficacy results after MR-guided risk-adapted stereotactic radiotherapy of infra-diaphragmatic oligometastases in a multicenter phase II trial.
Radiother Oncol
January 2025
Department of Oncology, Copenhagen University Hospital - Herlev and Gentofte, Borgmester Ib Juuls Vej 1, Herlev 2730 Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, Copenhagen 2200, Denmark.
Background And Purpose: The SOFT (Stereotactic ablative radiotherapy of infra-diaphragmatic sOFT tissue metastases) trial assesses the safety and efficacy of risk-adapted MR-guided stereotactic ablative radiotherapy (SABR) of infra-diaphragmatic soft tissue metastasis in patients with oligometastatic disease (OMD) (clinicaltrials.gov ID NCT04407897). This paper reports the one-year efficacy analysis and evaluates associations between local control (LC) and clinical and dosimetric parameters.
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