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Islet NO-Synthases, extracellular NO and glucose-stimulated insulin secretion: Possible impact of neuronal NO-Synthase on the pentose phosphate pathway.
PLoS One
January 2025
Department of Clinical Science, SUS, Division of Islet Cell Physiology, University of Lund, Malmö, Sweden.
The impact of islet neuronal nitric oxide synthase (nNOS) on glucose-stimulated insulin secretion (GSIS) is less understood. We investigated this issue by performing simultaneous measurements of the activity of nNOS versus inducible NOS (iNOS) in GSIS using isolated murine islets. Additionally, the significance of extracellular NO on GSIS was studied.
View Article and Find Full Text PDFIdentification of Glucose-6-Phosphate Dehydrogenase (G6PD) Inhibitors by Cheminformatics Approach.
Crit Rev Oncog
January 2025
Bioinformatics, Genomics and Proteomics, University of California, Irvine, CA, USA.
Glucose-6-phosphate dehydrogenase (G6PD) is an essential enzyme in the pentose phosphate pathway (PPP), a critical glucose metabolism pathway linked to cancer cell proliferation and metastasis. Inhibiting the PPP presents a promising approach to cancer treatment. The G6PD enzyme structure was obtained from the Protein Data Bank (PDB).
View Article and Find Full Text PDFThe pentose phosphate pathway controls oxidative protein folding and prevents ferroptosis in chondrocytes.
Nat Metab
January 2025
Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.
Bone lengthening and fracture repair depend on the anabolic properties of chondrocytes that function in an avascular milieu. The limited supply of oxygen and nutrients calls into question how biosynthesis and redox homeostasis are guaranteed. Here we show that glucose metabolism by the pentose phosphate pathway (PPP) is essential for endochondral ossification.
View Article and Find Full Text PDFThe hepatic clock synergizes with HIF-1α to regulate nucleotide availability during liver damage repair.
Nat Metab
January 2025
State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.
Nucleotide availability is crucial for DNA replication and repair; however, the coordinating mechanisms in vivo remain unclear. Here, we show that the circadian clock in the liver controls the activity of the pentose phosphate pathway (PPP) to support de novo nucleotide biosynthesis for DNA synthesis demands. We demonstrate that disrupting the hepatic clock by genetic manipulation or mistimed feeding impairs PPP activity in male mice, leading to nucleotide imbalance.
View Article and Find Full Text PDFDormancy: Metabolite pools prime the cyanobacterial dormancy-resuscitation switch.
Curr Biol
January 2025
Institute for Microbiology, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany. Electronic address:
Non-N-fixing cyanobacteria enter a state of dormancy when fixed nitrogen becomes limiting. Resuscitation from this state involves a complex program of events. A new study reveals how the dormancy-resuscitation switch is governed by metabolite-level control of glucose-6-phosphate dehydrogenase activity.
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