[Effect of antihepatocytotoxic serum on processes of cellular and intracellular regeneration of pathologically altered liver].

The parameters of the liver regeneration: mitotic index, DNA synthesis, nucleolar size of hepatocytes and histological structure, were studied in adult female rats with CCl4-affected liver during administration of the gamma-globulin fraction of antihepatocytotoxic serum (gamma-AHCS). It was shown that in various periods after exposure to CCl4 either the cellular processes of regeneration are predominant or the intracellular ones. gamma-AHCS (0.06 microgram protein per 100g body weight/one injection) intensifies and makes longer both the processes.