Cadmium injections during molar tooth development in the rat were strongly caries-promoting in female rats. Cadmium also partially negated the cariostatic effect of fluoridated drinking water in both male and female rats. The mechanism for the caries-promoting properties of cadmium is unknown, but may be related to cadmium uptake into enamel and dentin. Cadmium was taken up into molar enamel and dentin in proportion to the amount of cadmium administered, but cadmium did not influence uptake of fluoride onto eruted enamel. Calcium and ash concentrations in molar enamel were not altered by cadmium administration.
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