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Reactive lymphoid hyperplasia of the liver: A rare case report.

Clin Hemorheol Microcirc

June 2024

Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China.

Article Synopsis
  • - Hepatic reactive lymphoid hyperplasia (RLH) is a rare, benign condition that can mimic more serious liver diseases like cancer, posing challenges for diagnosis, particularly with imaging techniques and biopsies.
  • - In a case involving a 69-year-old woman, imaging suggested metastatic liver cancer, leading to surgery, but the final diagnosis revealed RLH after histopathological examination.
  • - The study emphasizes the importance of assessing specific imaging features, such as "wash-in and wash-out" patterns and diffusion on MRI, to better identify RLH in older women with isolated liver nodules and no cancer risk factors.
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Background: Benign lymphoid hyperplasia (BLH) is a rare lymphoproliferative disorder of normal polyclonal B lymphocytes, but is sometimes difficult to distinguish from malignancy.

Case: An 87-year-old man with a history of localized non-small cell lung cancer (NSCLC) was referred for evaluation and treatment of an elastic hard tumor in the left supraclavicular fossa one year after stereotactic ablative radiotherapy (SABR). Whole-body PET scan showed high 18F-fluorodeoxyglucose uptake in the left supraclavicular fossa, and a dia-gnosis of oligometastasis was made.

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Pulmonary nodular lymphoid hyperplasia, also known as pseudolymphoma, is an uncommon reactive lymphoproliferative disorder of unknown etiology that can be found in Sjögren's syndrome patients. Here, we present a case of a previously healthy woman in which the incidental finding of a lung mass compatible with nodular lymphoid hyperplasia led to the subsequent diagnosis of Sjögren's syndrome. We also performed a literature review for the association between both entities and described the main clinical aspects of the reported cases.

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