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Effect of cimetidine on the pharmacokinetics of fentiazac in rats.
J Pharm Sci
September 1993
Department of Pharmaceutics, College of Pharmacy, Seoul National University, Korea.
The effect of cimetidine (CM) on the pharmacokinetics of fentiazac (FT) was studied in six rats. FT was administered by intravenous (iv) bolus injection at doses of 5, 10, and 20 mg/kg to rats receiving iv infusion of saline (control) or CM. The infusion of CM was conducted to achieve steady-state plasma concentrations (Css) of CM of 30 and 60 micrograms/mL.
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