Weightless rats showed greater changes in the fluidelectrolyte metabolism and ion regulatory function of the kidneys than centrifuged rats. During water loads they exhibited an increased sodium excretion. During potassium loads they displayed a higher potassium excretion. The study of electrolyte composition of different kidney segments demonstrated a reduced potassium content in the wet cortical and medullary matter due to elevated tissue hydration. Kidney microdissection did not reveal any structural differences in nephrons of the weightless and centrifuged rats.

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