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Effect of Lipid Nanoparticle Physico-Chemical Properties and Composition on Their Interaction with the Immune System.
Pharmaceutics
November 2024
Department of Drug Sciences, University of Pavia, 27100 Pavia, Italy.
Lipid nanoparticles (LNPs) have shown promise as a delivery system for nucleic acid-based therapeutics, including DNA, siRNA, and mRNA vaccines. The immune system plays a critical role in the response to these nanocarriers, with innate immune cells initiating an early response and adaptive immune cells mediating a more specific reaction, sometimes leading to potential adverse effects. Recent studies have shown that the innate immune response to LNPs is mediated by Toll-like receptors (TLRs) and other pattern recognition receptors (PRRs), which recognize the lipid components of the nanoparticles.
View Article and Find Full Text PDFIdentification of QTLs and Key Genes Enhancing Lodging Resistance in Soybean Through Chemical and Physical Trait Analysis.
Plants (Basel)
December 2024
Key Laboratory of Soybean Biology in Chinese Ministry of Education, College of Agriculture, Northeast Agricultural University, Harbin 150030, China.
Lodging of soybean ( (L.) Merril.) significantly reduces seed yield and quality, particularly in high-yielding environments.
View Article and Find Full Text PDFAssociations Between Brominated Flame Retardant Exposure and Depression in Adults: A Cross-Sectional Study.
Toxics
December 2024
Nantong Key Laboratory of Environmental Toxicology, Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, China.
Background: Brominated flame retardants (BFRs) are a type of widespread pollutant that can be transmitted through particulate matter, such as dust in the air, and have been associated with various adverse health effects, such as diabetes, metabolic syndrome, and cardiovascular disease. However, there is limited research on the link between exposure to mixtures of BFRs and depression in the general population.
Methods: To analyze the association between exposure to BFRs and depression in the population, nationally representative data from the National Health and Nutrition Examination Survey (NHANES; 2005-2016) were used.
Analysis of Acute and Short-Term Fluoride Toxicity in Zebrafish Embryo and Sac-Fry Stages Based on Bayesian Model Averaging.
Toxics
December 2024
Department of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-communicable Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou 215123, China.
Acute and short-term toxicity tests are foundational to toxicology research. These tests offer preliminary insights into the fundamental toxicity characteristics of the chemicals under evaluation and provide essential data for chronic toxicity assessments. Fluoride is a common chemical in aquatic environments; however, the findings of toxicological data, such as LC for aquatic organisms, often exhibit inconsistency.
View Article and Find Full Text PDFPreparation and Efficacy Evaluation of Antihyperuricemic Peptides from Marine Sources.
Nutrients
December 2024
Engineering Research Center of Fujian and Taiwan Characteristic Marine Food Processing and Nutrition and Health, Ministry of Education, College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Marine-derived foods, often called blue foods, are promising sustainable alternatives to conventional food sources owing to their abundant amino acids and high protein content. Current treatments for hyperuricemia, a chronic condition attributed to purine metabolism disorders, are associated with various side effects. Novel peptide xanthine oxidase inhibitors have been discovered in the hydrolyzed products of marine fish and invertebrate proteins, which have demonstrated promising therapeutic potential by reducing uric acid levels in vitro and in vivo.
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