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Microcalcification and Tc-Pyrophosphate Uptake without Increased Bone Metabolism in Cardiac Tissue from Patients with Transthyretin Cardiac Amyloidosis.
Int J Mol Sci
January 2023
Department of Cardiovascular Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
Article Synopsis
- * In a study comparing ATTR-CA patients with those having amyloid light-chain cardiac amyloidosis and non-cardiac amyloidosis, ATTR-CA patients exhibited significantly higher Tc-pyrophosphate (PYP) uptake and more calcified microparticles in heart tissue.
- * Despite these findings, no increase in relevant bone metabolism-related genes was observed in ATTR-CA patients, indicating that active calcification mechanisms may not be responsible for the microcalcifications detected in their hearts.
Endomyocardial fibrosis (EMF) is a disease known to cause restrictive cardiomyopathy. It shows a high prevalence in tropical countries. Several triggering factors have been proposed.
View Article and Find Full Text PDFAn unusual tropical endomyocardial fibrosis: a case report.
Pan Afr Med J
February 2022
Department of Cardiology, Military Hospital Avicenne, University Cadi Ayyad, Marrakech, Morocco.
Tropical endomyocardial fibrosis (TEF) is a rare condition that occurs primarily in tropical countries, leading to a severe heart failure with heart restrictive filling patterns. Eosinophilia appears to be a trigger leading to the development of the disease; thus, numerous etiologic factors accompanied by eosinophilia have been postulated, although none have been confirmed. The massively calcified form of TEF is exceptional and easily diagnosed by multimodal imaging; but it is a very rare condition with high surgical challenge.
View Article and Find Full Text PDFCoexistence of apical hypertrophic cardiomyopathy and endomyocardial fibrosis with calcification: diagnosis using multimodality imaging.
ESC Heart Fail
December 2016
Aurora Cardiovascular Services.
A 48-year-old man from West Africa was evaluated for dyspnea. Echocardiography showed an echolucent mass at the left ventricular apex surrounded by a dense ridge of tissue, suggesting endomyocardial fibrosis (EMF). Doppler echocardiography showed restrictive hemodynamics and intramyocardial coronary blood flow at the hypertrophied apex, suggesting apical hypertrophic cardiomyopathy (ApHCM) with calcified thrombus.
View Article and Find Full Text PDFCalcified apical cardiomyopathy: a rare form of endomyocardial fibrosis.
J Cardiovasc Med (Hagerstown)
January 2015
aFondazione Toscana Gabriele Monasterio bCNR, Institute of Clinical Physiology, Pisa, Italy.
Endomyocardial fibrosis is a rare cardiomyopathy characterized by thickening of the endocardium, which leads to a restrictive phenotype. Differential diagnosis with other forms of cardiomyopathy may not always be straightforward and various imaging modalities are frequently necessary. In the present case, we report a patient with heart failure of uncertain origin, in whom, after an in-depth instrumental evaluation, a rare variant of endomyocardial fibrosis was diagnosed.
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